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Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis
Genome-wide association studies (GWASs) have reproducibly associated ∼40 susceptibility loci with psoriasis. However, the missing heritability is evident and the contributions of coding variants have not yet been systematically evaluated. Here, we present a large-scale whole-exome array analysis for...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403312/ https://www.ncbi.nlm.nih.gov/pubmed/25854761 http://dx.doi.org/10.1038/ncomms7793 |
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| author | Zuo, Xianbo Sun, Liangdan Yin, Xianyong Gao, Jinping Sheng, Yujun Xu, Jinhua Zhang, Jianzhong He, Chundi Qiu, Ying Wen, Guangdong Tian, Hongqing Zheng, Xiaodong Liu, Shengxiu Wang, Wenjun Li, Weiran Cheng, Yuyan Liu, Longdan Chang, Yan Wang, Zaixing Li, Zenggang Li, Longnian Wu, Jianping Fang, Ling Shen, Changbing Zhou, Fusheng Liang, Bo Chen, Gang Li, Hui Cui, Yong Xu, Aie Yang, Xueqin Hao, Fei Xu, Limin Fan, Xing Li, Yuzhen Wu, Rina Wang, Xiuli Liu, Xiaoming Zheng, Min Song, Shunpeng Ji, Bihua Fang, Hong Yu, Jianbin Sun, Yongxin Hui, Yan Zhang, Furen Yang, Rongya Yang, Sen Zhang, Xuejun |
| author_facet | Zuo, Xianbo Sun, Liangdan Yin, Xianyong Gao, Jinping Sheng, Yujun Xu, Jinhua Zhang, Jianzhong He, Chundi Qiu, Ying Wen, Guangdong Tian, Hongqing Zheng, Xiaodong Liu, Shengxiu Wang, Wenjun Li, Weiran Cheng, Yuyan Liu, Longdan Chang, Yan Wang, Zaixing Li, Zenggang Li, Longnian Wu, Jianping Fang, Ling Shen, Changbing Zhou, Fusheng Liang, Bo Chen, Gang Li, Hui Cui, Yong Xu, Aie Yang, Xueqin Hao, Fei Xu, Limin Fan, Xing Li, Yuzhen Wu, Rina Wang, Xiuli Liu, Xiaoming Zheng, Min Song, Shunpeng Ji, Bihua Fang, Hong Yu, Jianbin Sun, Yongxin Hui, Yan Zhang, Furen Yang, Rongya Yang, Sen Zhang, Xuejun |
| author_sort | Zuo, Xianbo |
| collection | PubMed |
| description | Genome-wide association studies (GWASs) have reproducibly associated ∼40 susceptibility loci with psoriasis. However, the missing heritability is evident and the contributions of coding variants have not yet been systematically evaluated. Here, we present a large-scale whole-exome array analysis for psoriasis consisting of 42,760 individuals. We discover 16 SNPs within 15 new genes/loci associated with psoriasis, including C1orf141, ZNF683, TMC6, AIM2, IL1RL1, CASR, SON, ZFYVE16, MTHFR, CCDC129, ZNF143, AP5B1, SYNE2, IFNGR2 and 3q26.2-q27 (P<5.00 × 10(−08)). In addition, we also replicate four known susceptibility loci TNIP1, NFKBIA, IL12B and LCE3D–LCE3E. These susceptibility variants identified in the current study collectively account for 1.9% of the psoriasis heritability. The variant within AIM2 is predicted to impact protein structure. Our findings increase the number of genetic risk factors for psoriasis and highlight new and plausible biological pathways in psoriasis. |
| format | Online Article Text |
| id | pubmed-4403312 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | Nature Publishing Group |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-44033122015-04-29 Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis Zuo, Xianbo Sun, Liangdan Yin, Xianyong Gao, Jinping Sheng, Yujun Xu, Jinhua Zhang, Jianzhong He, Chundi Qiu, Ying Wen, Guangdong Tian, Hongqing Zheng, Xiaodong Liu, Shengxiu Wang, Wenjun Li, Weiran Cheng, Yuyan Liu, Longdan Chang, Yan Wang, Zaixing Li, Zenggang Li, Longnian Wu, Jianping Fang, Ling Shen, Changbing Zhou, Fusheng Liang, Bo Chen, Gang Li, Hui Cui, Yong Xu, Aie Yang, Xueqin Hao, Fei Xu, Limin Fan, Xing Li, Yuzhen Wu, Rina Wang, Xiuli Liu, Xiaoming Zheng, Min Song, Shunpeng Ji, Bihua Fang, Hong Yu, Jianbin Sun, Yongxin Hui, Yan Zhang, Furen Yang, Rongya Yang, Sen Zhang, Xuejun Nat Commun Article Genome-wide association studies (GWASs) have reproducibly associated ∼40 susceptibility loci with psoriasis. However, the missing heritability is evident and the contributions of coding variants have not yet been systematically evaluated. Here, we present a large-scale whole-exome array analysis for psoriasis consisting of 42,760 individuals. We discover 16 SNPs within 15 new genes/loci associated with psoriasis, including C1orf141, ZNF683, TMC6, AIM2, IL1RL1, CASR, SON, ZFYVE16, MTHFR, CCDC129, ZNF143, AP5B1, SYNE2, IFNGR2 and 3q26.2-q27 (P<5.00 × 10(−08)). In addition, we also replicate four known susceptibility loci TNIP1, NFKBIA, IL12B and LCE3D–LCE3E. These susceptibility variants identified in the current study collectively account for 1.9% of the psoriasis heritability. The variant within AIM2 is predicted to impact protein structure. Our findings increase the number of genetic risk factors for psoriasis and highlight new and plausible biological pathways in psoriasis. Nature Publishing Group 2015-04-09 /pmc/articles/PMC4403312/ /pubmed/25854761 http://dx.doi.org/10.1038/ncomms7793 Text en Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| spellingShingle | Article Zuo, Xianbo Sun, Liangdan Yin, Xianyong Gao, Jinping Sheng, Yujun Xu, Jinhua Zhang, Jianzhong He, Chundi Qiu, Ying Wen, Guangdong Tian, Hongqing Zheng, Xiaodong Liu, Shengxiu Wang, Wenjun Li, Weiran Cheng, Yuyan Liu, Longdan Chang, Yan Wang, Zaixing Li, Zenggang Li, Longnian Wu, Jianping Fang, Ling Shen, Changbing Zhou, Fusheng Liang, Bo Chen, Gang Li, Hui Cui, Yong Xu, Aie Yang, Xueqin Hao, Fei Xu, Limin Fan, Xing Li, Yuzhen Wu, Rina Wang, Xiuli Liu, Xiaoming Zheng, Min Song, Shunpeng Ji, Bihua Fang, Hong Yu, Jianbin Sun, Yongxin Hui, Yan Zhang, Furen Yang, Rongya Yang, Sen Zhang, Xuejun Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis |
| title | Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis |
| title_full | Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis |
| title_fullStr | Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis |
| title_full_unstemmed | Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis |
| title_short | Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis |
| title_sort | whole-exome snp array identifies 15 new susceptibility loci for psoriasis |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403312/ https://www.ncbi.nlm.nih.gov/pubmed/25854761 http://dx.doi.org/10.1038/ncomms7793 |
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