Analysis of immunoglobulin transcripts and hypermutation following SHIV(AD8) infection and protein-plus-adjuvant immunization

Developing predictive animal models to assess how candidate vaccines and infection influence the ontogenies of Envelope (Env)-specific antibodies is critical for the development of an HIV vaccine. Here we use two nonhuman primate models to compare the roles of antigen persistence, diversity and inna...

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Detalles Bibliográficos
Autores principales: Francica, Joseph R., Sheng, Zizhang, Zhang, Zhenhai, Nishimura, Yoshiaki, Shingai, Masashi, Ramesh, Akshaya, Keele, Brandon F., Schmidt, Stephen D., Flynn, Barbara J., Darko, Sam, Lynch, Rebecca M., Yamamoto, Takuya, Matus-Nicodemos, Rodrigo, Wolinsky, David, Nason, Martha, Valiante, Nicholas M., Malyala, Padma, De Gregorio, Ennio, Barnett, Susan W., Singh, Manmohan, O'Hagan, Derek T., Koup, Richard A., Mascola, John R., Martin, Malcolm A., Kepler, Thomas B., Douek, Daniel C., Shapiro, Lawrence, Seder, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403371/
https://www.ncbi.nlm.nih.gov/pubmed/25858157
http://dx.doi.org/10.1038/ncomms7565

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