A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses

Synaptic plasticity is the cornerstone of processes underlying persistent nociceptive activity-induced changes in normal nociceptive sensitivity. Kalirin-7 is a multifunctional guanine-nucleotide-exchange factor (GEF) for Rho GTPases that is characterized by its localization at excitatory synapses,...

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Autores principales: Lu, Jianning, Luo, Ceng, Bali, Kiran Kumar, Xie, Rou-Gang, Mains, Richard E., Eipper, Betty A., Kuner, Rohini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403379/
https://www.ncbi.nlm.nih.gov/pubmed/25865668
http://dx.doi.org/10.1038/ncomms7820
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author Lu, Jianning
Luo, Ceng
Bali, Kiran Kumar
Xie, Rou-Gang
Mains, Richard E.
Eipper, Betty A.
Kuner, Rohini
author_facet Lu, Jianning
Luo, Ceng
Bali, Kiran Kumar
Xie, Rou-Gang
Mains, Richard E.
Eipper, Betty A.
Kuner, Rohini
author_sort Lu, Jianning
collection PubMed
description Synaptic plasticity is the cornerstone of processes underlying persistent nociceptive activity-induced changes in normal nociceptive sensitivity. Kalirin-7 is a multifunctional guanine-nucleotide-exchange factor (GEF) for Rho GTPases that is characterized by its localization at excitatory synapses, interactions with glutamate receptors and its ability to dynamically modulate the neuronal cytoskeleton. Here we show that spinally expressed Kalirin-7 is required for persistent nociceptive activity-dependent synaptic long-term potentiation as well as activity-dependent remodelling of synaptic spines in the spinal dorsal horn, thereby orchestrating functional and structural plasticity during the course of inflammatory pain.
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spelling pubmed-44033792015-04-29 A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses Lu, Jianning Luo, Ceng Bali, Kiran Kumar Xie, Rou-Gang Mains, Richard E. Eipper, Betty A. Kuner, Rohini Nat Commun Article Synaptic plasticity is the cornerstone of processes underlying persistent nociceptive activity-induced changes in normal nociceptive sensitivity. Kalirin-7 is a multifunctional guanine-nucleotide-exchange factor (GEF) for Rho GTPases that is characterized by its localization at excitatory synapses, interactions with glutamate receptors and its ability to dynamically modulate the neuronal cytoskeleton. Here we show that spinally expressed Kalirin-7 is required for persistent nociceptive activity-dependent synaptic long-term potentiation as well as activity-dependent remodelling of synaptic spines in the spinal dorsal horn, thereby orchestrating functional and structural plasticity during the course of inflammatory pain. Nature Pub. Group 2015-04-13 /pmc/articles/PMC4403379/ /pubmed/25865668 http://dx.doi.org/10.1038/ncomms7820 Text en Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Lu, Jianning
Luo, Ceng
Bali, Kiran Kumar
Xie, Rou-Gang
Mains, Richard E.
Eipper, Betty A.
Kuner, Rohini
A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses
title A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses
title_full A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses
title_fullStr A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses
title_full_unstemmed A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses
title_short A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses
title_sort role for kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403379/
https://www.ncbi.nlm.nih.gov/pubmed/25865668
http://dx.doi.org/10.1038/ncomms7820
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