Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

Pancreatic ductal adenocarcinoma (PDA) has a dismal prognosis and insights into both disease etiology and targeted intervention are needed. A total of 109 micro-dissected PDA cases were subjected to whole-exome sequencing. Microdissection enriches tumour cellularity and enhances mutation calling. He...

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Detalles Bibliográficos
Autores principales: Witkiewicz, Agnieszka K., McMillan, Elizabeth A., Balaji, Uthra, Baek, GuemHee, Lin, Wan-Chi, Mansour, John, Mollaee, Mehri, Wagner, Kay-Uwe, Koduru, Prasad, Yopp, Adam, Choti, Michael A., Yeo, Charles J., McCue, Peter, White, Michael A., Knudsen, Erik S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403382/
https://www.ncbi.nlm.nih.gov/pubmed/25855536
http://dx.doi.org/10.1038/ncomms7744

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