The Complex Myeloid Network of the Liver with Diverse Functional Capacity at Steady State and in Inflammation

In recent years, it has been an explosion of information regarding the role of various myeloid cells in liver pathology. Macrophages and dendritic cell (DC) play crucial roles in multiple chronic liver diseases such as fibrosis and non-alcoholic fatty liver disease (NAFLD). The complexity of myeloid...

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Autores principales: Eckert, Christoph, Klein, Niklas, Kornek, Miroslaw, Lukacs-Kornek, Veronika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403526/
https://www.ncbi.nlm.nih.gov/pubmed/25941527
http://dx.doi.org/10.3389/fimmu.2015.00179
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author Eckert, Christoph
Klein, Niklas
Kornek, Miroslaw
Lukacs-Kornek, Veronika
author_facet Eckert, Christoph
Klein, Niklas
Kornek, Miroslaw
Lukacs-Kornek, Veronika
author_sort Eckert, Christoph
collection PubMed
description In recent years, it has been an explosion of information regarding the role of various myeloid cells in liver pathology. Macrophages and dendritic cell (DC) play crucial roles in multiple chronic liver diseases such as fibrosis and non-alcoholic fatty liver disease (NAFLD). The complexity of myeloid cell populations and the missing exclusive marker combination make the interpretation of the data often extremely difficult. The current review aims to summarize the multiple roles of macrophages and DCs in chronic liver diseases, especially pointing out how these cells influence liver immune and parenchymal cells thereby altering liver function and pathology. Moreover, the review outlines the currently known marker combinations for the identification of these cell populations for the study of their role in liver immunology.
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spelling pubmed-44035262015-05-04 The Complex Myeloid Network of the Liver with Diverse Functional Capacity at Steady State and in Inflammation Eckert, Christoph Klein, Niklas Kornek, Miroslaw Lukacs-Kornek, Veronika Front Immunol Immunology In recent years, it has been an explosion of information regarding the role of various myeloid cells in liver pathology. Macrophages and dendritic cell (DC) play crucial roles in multiple chronic liver diseases such as fibrosis and non-alcoholic fatty liver disease (NAFLD). The complexity of myeloid cell populations and the missing exclusive marker combination make the interpretation of the data often extremely difficult. The current review aims to summarize the multiple roles of macrophages and DCs in chronic liver diseases, especially pointing out how these cells influence liver immune and parenchymal cells thereby altering liver function and pathology. Moreover, the review outlines the currently known marker combinations for the identification of these cell populations for the study of their role in liver immunology. Frontiers Media S.A. 2015-04-20 /pmc/articles/PMC4403526/ /pubmed/25941527 http://dx.doi.org/10.3389/fimmu.2015.00179 Text en Copyright © 2015 Eckert, Klein, Kornek and Lukacs-Kornek. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Eckert, Christoph
Klein, Niklas
Kornek, Miroslaw
Lukacs-Kornek, Veronika
The Complex Myeloid Network of the Liver with Diverse Functional Capacity at Steady State and in Inflammation
title The Complex Myeloid Network of the Liver with Diverse Functional Capacity at Steady State and in Inflammation
title_full The Complex Myeloid Network of the Liver with Diverse Functional Capacity at Steady State and in Inflammation
title_fullStr The Complex Myeloid Network of the Liver with Diverse Functional Capacity at Steady State and in Inflammation
title_full_unstemmed The Complex Myeloid Network of the Liver with Diverse Functional Capacity at Steady State and in Inflammation
title_short The Complex Myeloid Network of the Liver with Diverse Functional Capacity at Steady State and in Inflammation
title_sort complex myeloid network of the liver with diverse functional capacity at steady state and in inflammation
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403526/
https://www.ncbi.nlm.nih.gov/pubmed/25941527
http://dx.doi.org/10.3389/fimmu.2015.00179
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