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Management of severe sepsis: advances, challenges, and current status
The complexity of treating severe sepsis and septic shock has been elucidated in myriad studies, particularly in the past 10 years. The development of clinical guidelines, insight into the effect of bundle elements, and results of clinical trials have brought to light further opportunities and quest...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403600/ https://www.ncbi.nlm.nih.gov/pubmed/25926718 http://dx.doi.org/10.2147/DDDT.S78757 |
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author | Martin-Loeches, Ignacio Levy, Mitchell M Artigas, Antonio |
author_facet | Martin-Loeches, Ignacio Levy, Mitchell M Artigas, Antonio |
author_sort | Martin-Loeches, Ignacio |
collection | PubMed |
description | The complexity of treating severe sepsis and septic shock has been elucidated in myriad studies, particularly in the past 10 years. The development of clinical guidelines, insight into the effect of bundle elements, and results of clinical trials have brought to light further opportunities and questions in the approach to pharmaceutical interventions for the global challenge to save lives and reduce healthcare costs. Therapeutic interventions including fluid resuscitation, hemodynamic monitoring, glycemic control, corticosteroids, and antimicrobial therapy and stewardship inform outcomes. Research on biomarkers, use of mesenchymal stem cells, blood purification, immunoglobulins, and antioxidative treatments apropos the immune response may soon yield viable therapies. |
format | Online Article Text |
id | pubmed-4403600 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-44036002015-04-29 Management of severe sepsis: advances, challenges, and current status Martin-Loeches, Ignacio Levy, Mitchell M Artigas, Antonio Drug Des Devel Ther Review The complexity of treating severe sepsis and septic shock has been elucidated in myriad studies, particularly in the past 10 years. The development of clinical guidelines, insight into the effect of bundle elements, and results of clinical trials have brought to light further opportunities and questions in the approach to pharmaceutical interventions for the global challenge to save lives and reduce healthcare costs. Therapeutic interventions including fluid resuscitation, hemodynamic monitoring, glycemic control, corticosteroids, and antimicrobial therapy and stewardship inform outcomes. Research on biomarkers, use of mesenchymal stem cells, blood purification, immunoglobulins, and antioxidative treatments apropos the immune response may soon yield viable therapies. Dove Medical Press 2015-04-09 /pmc/articles/PMC4403600/ /pubmed/25926718 http://dx.doi.org/10.2147/DDDT.S78757 Text en © 2015 Martin-Loeches et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Martin-Loeches, Ignacio Levy, Mitchell M Artigas, Antonio Management of severe sepsis: advances, challenges, and current status |
title | Management of severe sepsis: advances, challenges, and current status |
title_full | Management of severe sepsis: advances, challenges, and current status |
title_fullStr | Management of severe sepsis: advances, challenges, and current status |
title_full_unstemmed | Management of severe sepsis: advances, challenges, and current status |
title_short | Management of severe sepsis: advances, challenges, and current status |
title_sort | management of severe sepsis: advances, challenges, and current status |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403600/ https://www.ncbi.nlm.nih.gov/pubmed/25926718 http://dx.doi.org/10.2147/DDDT.S78757 |
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