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Management of severe sepsis: advances, challenges, and current status

The complexity of treating severe sepsis and septic shock has been elucidated in myriad studies, particularly in the past 10 years. The development of clinical guidelines, insight into the effect of bundle elements, and results of clinical trials have brought to light further opportunities and quest...

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Detalles Bibliográficos
Autores principales: Martin-Loeches, Ignacio, Levy, Mitchell M, Artigas, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403600/
https://www.ncbi.nlm.nih.gov/pubmed/25926718
http://dx.doi.org/10.2147/DDDT.S78757
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author Martin-Loeches, Ignacio
Levy, Mitchell M
Artigas, Antonio
author_facet Martin-Loeches, Ignacio
Levy, Mitchell M
Artigas, Antonio
author_sort Martin-Loeches, Ignacio
collection PubMed
description The complexity of treating severe sepsis and septic shock has been elucidated in myriad studies, particularly in the past 10 years. The development of clinical guidelines, insight into the effect of bundle elements, and results of clinical trials have brought to light further opportunities and questions in the approach to pharmaceutical interventions for the global challenge to save lives and reduce healthcare costs. Therapeutic interventions including fluid resuscitation, hemodynamic monitoring, glycemic control, corticosteroids, and antimicrobial therapy and stewardship inform outcomes. Research on biomarkers, use of mesenchymal stem cells, blood purification, immunoglobulins, and antioxidative treatments apropos the immune response may soon yield viable therapies.
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spelling pubmed-44036002015-04-29 Management of severe sepsis: advances, challenges, and current status Martin-Loeches, Ignacio Levy, Mitchell M Artigas, Antonio Drug Des Devel Ther Review The complexity of treating severe sepsis and septic shock has been elucidated in myriad studies, particularly in the past 10 years. The development of clinical guidelines, insight into the effect of bundle elements, and results of clinical trials have brought to light further opportunities and questions in the approach to pharmaceutical interventions for the global challenge to save lives and reduce healthcare costs. Therapeutic interventions including fluid resuscitation, hemodynamic monitoring, glycemic control, corticosteroids, and antimicrobial therapy and stewardship inform outcomes. Research on biomarkers, use of mesenchymal stem cells, blood purification, immunoglobulins, and antioxidative treatments apropos the immune response may soon yield viable therapies. Dove Medical Press 2015-04-09 /pmc/articles/PMC4403600/ /pubmed/25926718 http://dx.doi.org/10.2147/DDDT.S78757 Text en © 2015 Martin-Loeches et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Martin-Loeches, Ignacio
Levy, Mitchell M
Artigas, Antonio
Management of severe sepsis: advances, challenges, and current status
title Management of severe sepsis: advances, challenges, and current status
title_full Management of severe sepsis: advances, challenges, and current status
title_fullStr Management of severe sepsis: advances, challenges, and current status
title_full_unstemmed Management of severe sepsis: advances, challenges, and current status
title_short Management of severe sepsis: advances, challenges, and current status
title_sort management of severe sepsis: advances, challenges, and current status
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403600/
https://www.ncbi.nlm.nih.gov/pubmed/25926718
http://dx.doi.org/10.2147/DDDT.S78757
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