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Challenges in Enzymatic Route of Mannitol Production

Mannitol is an important biochemical often used as medicine and in food sector, yet its biotechnological is not preffered in Industry for large scale production, which may be due to the multistep mechanism involved in hydrogenation and reduction. This paper is a comparative preview covering present...

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Detalles Bibliográficos
Autores principales: Bhatt, Sheelendra Mangal, Mohan, Anand, Srivastava, Suresh Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403613/
https://www.ncbi.nlm.nih.gov/pubmed/25969783
http://dx.doi.org/10.5402/2013/914187
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author Bhatt, Sheelendra Mangal
Mohan, Anand
Srivastava, Suresh Kumar
author_facet Bhatt, Sheelendra Mangal
Mohan, Anand
Srivastava, Suresh Kumar
author_sort Bhatt, Sheelendra Mangal
collection PubMed
description Mannitol is an important biochemical often used as medicine and in food sector, yet its biotechnological is not preffered in Industry for large scale production, which may be due to the multistep mechanism involved in hydrogenation and reduction. This paper is a comparative preview covering present chemical and biotechnological approaches existing today for mannitol production at industrial scale. Biotechnological routes are suitable for adaptation at industrial level for mannitol production, and whatever concerns are there had been discussed in detail, namely, raw materials, broad range of enzymes with high activity at elevated temperature suitable for use in reactor, cofactor limitation, reduced by-product formation, end product inhibition, and reduced utilization of mannitol for enhancing the yield with maximum volumetric productivity.
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spelling pubmed-44036132015-05-12 Challenges in Enzymatic Route of Mannitol Production Bhatt, Sheelendra Mangal Mohan, Anand Srivastava, Suresh Kumar ISRN Biotechnol Review Article Mannitol is an important biochemical often used as medicine and in food sector, yet its biotechnological is not preffered in Industry for large scale production, which may be due to the multistep mechanism involved in hydrogenation and reduction. This paper is a comparative preview covering present chemical and biotechnological approaches existing today for mannitol production at industrial scale. Biotechnological routes are suitable for adaptation at industrial level for mannitol production, and whatever concerns are there had been discussed in detail, namely, raw materials, broad range of enzymes with high activity at elevated temperature suitable for use in reactor, cofactor limitation, reduced by-product formation, end product inhibition, and reduced utilization of mannitol for enhancing the yield with maximum volumetric productivity. Hindawi Publishing Corporation 2012-12-26 /pmc/articles/PMC4403613/ /pubmed/25969783 http://dx.doi.org/10.5402/2013/914187 Text en Copyright © 2013 Sheelendra Mangal Bhatt et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Bhatt, Sheelendra Mangal
Mohan, Anand
Srivastava, Suresh Kumar
Challenges in Enzymatic Route of Mannitol Production
title Challenges in Enzymatic Route of Mannitol Production
title_full Challenges in Enzymatic Route of Mannitol Production
title_fullStr Challenges in Enzymatic Route of Mannitol Production
title_full_unstemmed Challenges in Enzymatic Route of Mannitol Production
title_short Challenges in Enzymatic Route of Mannitol Production
title_sort challenges in enzymatic route of mannitol production
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403613/
https://www.ncbi.nlm.nih.gov/pubmed/25969783
http://dx.doi.org/10.5402/2013/914187
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