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Challenges in Enzymatic Route of Mannitol Production
Mannitol is an important biochemical often used as medicine and in food sector, yet its biotechnological is not preffered in Industry for large scale production, which may be due to the multistep mechanism involved in hydrogenation and reduction. This paper is a comparative preview covering present...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403613/ https://www.ncbi.nlm.nih.gov/pubmed/25969783 http://dx.doi.org/10.5402/2013/914187 |
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author | Bhatt, Sheelendra Mangal Mohan, Anand Srivastava, Suresh Kumar |
author_facet | Bhatt, Sheelendra Mangal Mohan, Anand Srivastava, Suresh Kumar |
author_sort | Bhatt, Sheelendra Mangal |
collection | PubMed |
description | Mannitol is an important biochemical often used as medicine and in food sector, yet its biotechnological is not preffered in Industry for large scale production, which may be due to the multistep mechanism involved in hydrogenation and reduction. This paper is a comparative preview covering present chemical and biotechnological approaches existing today for mannitol production at industrial scale. Biotechnological routes are suitable for adaptation at industrial level for mannitol production, and whatever concerns are there had been discussed in detail, namely, raw materials, broad range of enzymes with high activity at elevated temperature suitable for use in reactor, cofactor limitation, reduced by-product formation, end product inhibition, and reduced utilization of mannitol for enhancing the yield with maximum volumetric productivity. |
format | Online Article Text |
id | pubmed-4403613 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-44036132015-05-12 Challenges in Enzymatic Route of Mannitol Production Bhatt, Sheelendra Mangal Mohan, Anand Srivastava, Suresh Kumar ISRN Biotechnol Review Article Mannitol is an important biochemical often used as medicine and in food sector, yet its biotechnological is not preffered in Industry for large scale production, which may be due to the multistep mechanism involved in hydrogenation and reduction. This paper is a comparative preview covering present chemical and biotechnological approaches existing today for mannitol production at industrial scale. Biotechnological routes are suitable for adaptation at industrial level for mannitol production, and whatever concerns are there had been discussed in detail, namely, raw materials, broad range of enzymes with high activity at elevated temperature suitable for use in reactor, cofactor limitation, reduced by-product formation, end product inhibition, and reduced utilization of mannitol for enhancing the yield with maximum volumetric productivity. Hindawi Publishing Corporation 2012-12-26 /pmc/articles/PMC4403613/ /pubmed/25969783 http://dx.doi.org/10.5402/2013/914187 Text en Copyright © 2013 Sheelendra Mangal Bhatt et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Bhatt, Sheelendra Mangal Mohan, Anand Srivastava, Suresh Kumar Challenges in Enzymatic Route of Mannitol Production |
title | Challenges in Enzymatic Route of Mannitol Production |
title_full | Challenges in Enzymatic Route of Mannitol Production |
title_fullStr | Challenges in Enzymatic Route of Mannitol Production |
title_full_unstemmed | Challenges in Enzymatic Route of Mannitol Production |
title_short | Challenges in Enzymatic Route of Mannitol Production |
title_sort | challenges in enzymatic route of mannitol production |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403613/ https://www.ncbi.nlm.nih.gov/pubmed/25969783 http://dx.doi.org/10.5402/2013/914187 |
work_keys_str_mv | AT bhattsheelendramangal challengesinenzymaticrouteofmannitolproduction AT mohananand challengesinenzymaticrouteofmannitolproduction AT srivastavasureshkumar challengesinenzymaticrouteofmannitolproduction |