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Nimotuzumab enhances radiation sensitivity of NSCLC H292 cells in vitro by blocking epidermal growth factor receptor nuclear translocation and inhibiting radiation-induced DNA damage repair

BACKGROUND: The epidermal growth factor receptor (EGFR) signaling pathway plays a significant role in radiation resistance. There is evidence that EGFR nuclear translocation is associated with DNA double-strand breaks (DSB) repair. Nimotuzumab has shown the effect of radiosensitization in various ca...

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Detalles Bibliográficos
Autores principales:	Teng, Kai, Zhang, Yong, Hu, Xiaoyan, Ding, Yihui, Gong, Rui, Liu, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403694/ https://www.ncbi.nlm.nih.gov/pubmed/25926742 http://dx.doi.org/10.2147/OTT.S77283

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