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Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction

Lymphatic endothelial cells (LECs) directly express peripheral tissue antigens and induce CD8 T-cell deletional tolerance. LECs express MHC-II molecules, suggesting they might also tolerize CD4 T cells. We demonstrate that when β-galactosidase (β-gal) is expressed in LECs, β-gal-specific CD8 T cells...

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Detalles Bibliográficos
Autores principales:	Rouhani, Sherin J., Eccles, Jacob D., Riccardi, Priscila, Peske, J. David, Tewalt, Eric F., Cohen, Jarish N., Liblau, Roland, Mäkinen, Taija, Engelhard, Victor H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403767/ https://www.ncbi.nlm.nih.gov/pubmed/25857745 http://dx.doi.org/10.1038/ncomms7771

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