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SMART: physical activity and cerebral metabolism in older people: study protocol for a randomised controlled trial

BACKGROUND: Physical activity exerts a variety of long-term health benefits in older adults. In particular, it is assumed to be a protective factor against cognitive decline and dementia. METHODS/DESIGN: Randomised controlled assessor blinded 2-armed trial (n = 60) to explore the exercise- induced n...

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Autores principales: Fleckenstein, Johannes, Matura, Silke, Engeroff, Tobias, Füzéki, Eszter, Tesky, Valentina A, Pilatus, Ulrich, Hattingen, Elke, Deichmann, Ralf, Vogt, Lutz, Banzer, Winfried, Pantel, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403840/
https://www.ncbi.nlm.nih.gov/pubmed/25872789
http://dx.doi.org/10.1186/s13063-015-0662-9
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author Fleckenstein, Johannes
Matura, Silke
Engeroff, Tobias
Füzéki, Eszter
Tesky, Valentina A
Pilatus, Ulrich
Hattingen, Elke
Deichmann, Ralf
Vogt, Lutz
Banzer, Winfried
Pantel, Johannes
author_facet Fleckenstein, Johannes
Matura, Silke
Engeroff, Tobias
Füzéki, Eszter
Tesky, Valentina A
Pilatus, Ulrich
Hattingen, Elke
Deichmann, Ralf
Vogt, Lutz
Banzer, Winfried
Pantel, Johannes
author_sort Fleckenstein, Johannes
collection PubMed
description BACKGROUND: Physical activity exerts a variety of long-term health benefits in older adults. In particular, it is assumed to be a protective factor against cognitive decline and dementia. METHODS/DESIGN: Randomised controlled assessor blinded 2-armed trial (n = 60) to explore the exercise- induced neuroprotective and metabolic effects on the brain in cognitively healthy older adults. Participants (age ≥ 65), recruited within the setting of assisted living facilities and newspaper advertisements are allocated to a 12-week individualised aerobic exercise programme intervention or a 12-week waiting control group. Total follow-up is 24 weeks. The main outcome is the change in cerebral metabolism as assessed with Magnetic Resonance Spectroscopic Imaging reflecting changes of cerebral N-acetyl-aspartate and of markers of neuronal energy reserve. Imaging also measures changes in cortical grey matter volume. Secondary outcomes include a broad range of psychometric (cognition) and movement-related parameters such as nutrition, history of physical activity, history of pain and functional diagnostics. Participants are allocated to either the intervention or control group using a computer-generated randomisation sequence. The exercise physiologist in charge of training opens sealed and opaque envelopes and informs participants about group allocation. For organisational reasons, he schedules the participants for upcoming assessments and exercise in groups of five. All assessors and study personal other than exercise physiologists are blinded. DISCUSSION: Magnetic Resonance Spectroscopic Imaging gives a deeper insight into mechanisms of exercise-induced changes in brain metabolism. As follow-up lasts for 6 months, this study is able to explore the mid-term cerebral metabolic effects of physical activity assuming that an individually tailored aerobic ergometer training has the potential to counteract brain ageing. TRIAL REGISTRATION: NCT02343029 (clinicaltrials.gov; 12 January 2015).
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spelling pubmed-44038402015-04-21 SMART: physical activity and cerebral metabolism in older people: study protocol for a randomised controlled trial Fleckenstein, Johannes Matura, Silke Engeroff, Tobias Füzéki, Eszter Tesky, Valentina A Pilatus, Ulrich Hattingen, Elke Deichmann, Ralf Vogt, Lutz Banzer, Winfried Pantel, Johannes Trials Study Protocol BACKGROUND: Physical activity exerts a variety of long-term health benefits in older adults. In particular, it is assumed to be a protective factor against cognitive decline and dementia. METHODS/DESIGN: Randomised controlled assessor blinded 2-armed trial (n = 60) to explore the exercise- induced neuroprotective and metabolic effects on the brain in cognitively healthy older adults. Participants (age ≥ 65), recruited within the setting of assisted living facilities and newspaper advertisements are allocated to a 12-week individualised aerobic exercise programme intervention or a 12-week waiting control group. Total follow-up is 24 weeks. The main outcome is the change in cerebral metabolism as assessed with Magnetic Resonance Spectroscopic Imaging reflecting changes of cerebral N-acetyl-aspartate and of markers of neuronal energy reserve. Imaging also measures changes in cortical grey matter volume. Secondary outcomes include a broad range of psychometric (cognition) and movement-related parameters such as nutrition, history of physical activity, history of pain and functional diagnostics. Participants are allocated to either the intervention or control group using a computer-generated randomisation sequence. The exercise physiologist in charge of training opens sealed and opaque envelopes and informs participants about group allocation. For organisational reasons, he schedules the participants for upcoming assessments and exercise in groups of five. All assessors and study personal other than exercise physiologists are blinded. DISCUSSION: Magnetic Resonance Spectroscopic Imaging gives a deeper insight into mechanisms of exercise-induced changes in brain metabolism. As follow-up lasts for 6 months, this study is able to explore the mid-term cerebral metabolic effects of physical activity assuming that an individually tailored aerobic ergometer training has the potential to counteract brain ageing. TRIAL REGISTRATION: NCT02343029 (clinicaltrials.gov; 12 January 2015). BioMed Central 2015-04-11 /pmc/articles/PMC4403840/ /pubmed/25872789 http://dx.doi.org/10.1186/s13063-015-0662-9 Text en © Fleckenstein et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Study Protocol
Fleckenstein, Johannes
Matura, Silke
Engeroff, Tobias
Füzéki, Eszter
Tesky, Valentina A
Pilatus, Ulrich
Hattingen, Elke
Deichmann, Ralf
Vogt, Lutz
Banzer, Winfried
Pantel, Johannes
SMART: physical activity and cerebral metabolism in older people: study protocol for a randomised controlled trial
title SMART: physical activity and cerebral metabolism in older people: study protocol for a randomised controlled trial
title_full SMART: physical activity and cerebral metabolism in older people: study protocol for a randomised controlled trial
title_fullStr SMART: physical activity and cerebral metabolism in older people: study protocol for a randomised controlled trial
title_full_unstemmed SMART: physical activity and cerebral metabolism in older people: study protocol for a randomised controlled trial
title_short SMART: physical activity and cerebral metabolism in older people: study protocol for a randomised controlled trial
title_sort smart: physical activity and cerebral metabolism in older people: study protocol for a randomised controlled trial
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403840/
https://www.ncbi.nlm.nih.gov/pubmed/25872789
http://dx.doi.org/10.1186/s13063-015-0662-9
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