Cargando…

PinX1 inhibits the invasion and metastasis of human breast cancer via suppressing NF-κB/MMP-9 signaling pathway

BACKGROUND: PinX1 (PIN2/TRF1-interacting telomerase inhibitor 1) was suggested to be correlated with tumor progression. This study was designed to evaluate the role of PinX1 in human breast cancer. METHODS: To evaluate the function of PinX1 in breast cancer, we used a tissue microarray (TMA) of 405...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shi, Meilin, Cao, Menghan, Song, Jun, Liu, Qinghua, Li, Hailong, Meng, Fei, Pan, Zhenqiang, Bai, Jin, Zheng, Junnian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404090/ https://www.ncbi.nlm.nih.gov/pubmed/25888829 http://dx.doi.org/10.1186/s12943-015-0332-2

Ejemplares similares

PinX1 serves as a potential prognostic indicator for clear cell renal cell carcinoma and inhibits its invasion and metastasis by suppressing MMP-2 via NF-κB-dependent transcription
por: Li, Hai-Long, et al.
Publicado: (2015)

PinX1t, a Novel PinX1 Transcript Variant, Positively Regulates Cardiogenesis of Embryonic Stem Cells
por: Chan, Hing Chung, et al.
Publicado: (2020)

Nucleophosmin Interacts with PIN2/TERF1-interacting Telomerase Inhibitor 1 (PinX1) and Attenuates the PinX1 Inhibition on Telomerase Activity
por: Cheung, Derek Hang-Cheong, et al.
Publicado: (2017)

PinX1: structure, regulation and its functions in cancer
por: Li, Hai-Long, et al.
Publicado: (2016)

Increased Stability of Nucleolar PinX1 in the Presence of TERT
por: Keo, Ponnarath, et al.
Publicado: (2015)

PinX1 regulation of telomerase activity and apoptosis in nasopharyngeal carcinoma cells
por: Lai, Xiao-Fen, et al.
Publicado: (2012)

Hesperidin Inhibits Lung Cancer In Vitro and In Vivo Through PinX1
por: Yao, Yang, et al.
Publicado: (2022)

Reduced expression of PinX1 correlates to progressive features in patients with prostate cancer
por: Shi, Rong, et al.
Publicado: (2014)

Selective killing of Burkitt's lymphoma cells by mBAFF-targeted delivery of PinX1
por: Zhang, L, et al.
Publicado: (2011)

Low expression of PinX1 is associated with malignant behavior in basal-like breast cancer
por: Feng, Yu-Zhen, et al.
Publicado: (2017)

The PinX1/NPM interaction associates with hTERT in early-S phase and facilitates telomerase activation
por: Ho, Sai-Tim, et al.
Publicado: (2019)

PinX1: a sought-after major tumor suppressor at human chromosome 8p23
por: Zhou, Xiao Zhen
Publicado: (2011)

Expression of FOXC2, PinX1, Ki-67 and Cyclin D1 in cutaneous cell carcinoma
por: Zhao, Haiying, et al.
Publicado: (2017)

PinX1 suppresses tumorigenesis by negatively regulating telomerase/telomeres in colorectal carcinoma cells and is a promising molecular marker for patient prognosis
por: Qian, Dong, et al.
Publicado: (2016)

PinX1-siRNA/mPEG-PEI-SPION combined with doxorubicin enhances the inhibition of glioma growth
por: LONG, LING, et al.
Publicado: (2014)

PinX1 suppresses bladder urothelial carcinoma cell proliferation via the inhibition of telomerase activity and p16/cyclin D1 pathway
por: Liu, Jian-Ye, et al.
Publicado: (2013)

PinX1 Is a Potential Prognostic Factor for Non-Small-Cell Lung Cancer and Inhibits Cell Proliferation and Migration
por: Wang, Shengguang, et al.
Publicado: (2017)

Genetic profile and biological implication of PIN2/TRF1-interacting telomerase inhibitor 1 (PinX1) in human cancers: an analysis using The Cancer Genome Atlas
por: Huang, Wei-Juan, et al.
Publicado: (2017)

Pin2 telomeric repeat factor 1-interacting telomerase inhibitor 1 (PinX1) inhibits nasopharyngeal cancer cell stemness: implication for cancer progression and therapeutic targeting
por: Yu, Chaosheng, et al.
Publicado: (2020)

The Role of PinX1 in Growth Control of Breast Cancer Cells and Its Potential Molecular Mechanism by mRNA and lncRNA Expression Profiles Screening
por: Shi, Rong, et al.
Publicado: (2014)

UTP14A, DKC1, DDX10, PinX1, and ESF1 Modulate Cardiac Angiogenesis Leading to Obesity-Induced Cardiac Injury
por: Pan, Xiaoyu, et al.
Publicado: (2022)

The depletion of PinX1 involved in the tumorigenesis of non-small cell lung cancer promotes cell proliferation via p15/cyclin D1 pathway
por: Tian, Xiao-Peng, et al.
Publicado: (2017)

Indacaterol Inhibits Tumor Cell Invasiveness and MMP-9 Expression by Suppressing IKK/NF-κB Activation
por: Lee, Su Ui, et al.
Publicado: (2014)

MPPa-PDT suppresses breast tumor migration/invasion by inhibiting Akt-NF-κB-dependent MMP-9 expression via ROS
por: Huang, Liyi, et al.
Publicado: (2019)

NF-κB inhibition is associated with OPN/MMP-9 downregulation in cutaneous melanoma
por: Guarneri, Claudio, et al.
Publicado: (2017)

Resveratrol Inhibits MMP3 and MMP9 Expression and Secretion by Suppressing TLR4/NF-κB/STAT3 Activation in Ox-LDL-Treated HUVECs
por: Zhang, Ming, et al.
Publicado: (2019)

RHCG Suppresses Tumorigenicity and Metastasis in Esophageal Squamous Cell Carcinoma via Inhibiting NF-κB Signaling and MMP1 Expression
por: Ming, Xiao-Yan, et al.
Publicado: (2018)

Thrombopoietin could protect cerebral tissue against ischemia-reperfusion injury by suppressing NF-κB and MMP-9 expression in rats
por: Wu, Wenjuan, et al.
Publicado: (2018)

Inhibitory effect of midazolam on MMP-9, MMP-1 and MMP-13 expression in PMA-stimulated human chondrocytes via recovery of NF-κB signaling
por: Wang, Jen-Jui, et al.
Publicado: (2012)

Thrombospondin‐2 stimulates MMP‐9 production and promotes osteosarcoma metastasis via the PLC, PKC, c‐Src and NF‐κB activation
por: Liu, Ju‐Fang, et al.
Publicado: (2020)

Role of RUNX3 in Suppressing Metastasis and Angiogenesis of Human Prostate Cancer
por: Chen, Feifei, et al.
Publicado: (2014)

Pin1 promotes pancreatic cancer progression and metastasis by activation of NF‐κB‐IL‐18 feedback loop
por: Sun, Qiqing, et al.
Publicado: (2020)

BRMS1 Suppresses Glioma Progression by Regulating Invasion, Migration and Adhesion of Glioma Cells
por: Mei, Pengjin, et al.
Publicado: (2014)

Isothiocyanates suppress the invasion and metastasis of tumors by targeting FAK/MMP-9 activity
por: Jeong, Yun-Jeong, et al.
Publicado: (2017)

Glaucine inhibits breast cancer cell migration and invasion by inhibiting MMP-9 gene expression through the suppression of NF-κB activation
por: Kang, Hyereen, et al.
Publicado: (2015)

MST1 Suppression Reduces Early Brain Injury by Inhibiting the NF-κB/MMP-9 Pathway after Subarachnoid Hemorrhage in Mice
por: Qu, Jie, et al.
Publicado: (2018)

[Retracted] Pin2/TRF1‑binding protein X1 inhibits colorectal cancer cell migration and invasion in vitro and metastasis in vivo via the nuclear factor‑κB signaling pathway
por: Jiang, Tao, et al.
Publicado: (2023)

Nuclear HDAC6 inhibits invasion by suppressing NF-κB/MMP2 and is inversely correlated with metastasis of non-small cell lung cancer
por: Yang, Chih-Jen, et al.
Publicado: (2015)

Combination of ACY-241 and JQ1 Synergistically Suppresses Metastasis of HNSCC via Regulation of MMP-2 and MMP-9
por: Cho, Ha Young, et al.
Publicado: (2020)

NKILA inhibits NF-κB signaling and suppresses tumor metastasis
por: Ke, Shun, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_vlaehe8ubgbughbt8bklto9mr4