The Novel Extracellular Cyclophilin A (CyPA) - Inhibitor MM284 Reduces Myocardial Inflammation and Remodeling in a Mouse Model of Troponin I -Induced Myocarditis

Cyclophilins are a group of highly conserved cytosolic enzymes that have a peptidylprolyl cis/trans isomerase activity. Cyclophilin A (CyPA) can be secreted in the extracellular space by inflammatory cells and upon cell death. The presence of CyPA in patients with non-ischemic cardiomyopathy is asso...

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Detalles Bibliográficos
Autores principales: Heinzmann, David, Bangert, Anna, Müller, Anna-Maria, von Ungern-Sternberg, Saskia N. I., Emschermann, Frederic, Schönberger, Tanja, Chatterjee, Madhumita, Mack, Andreas F., Klingel, Karin, Kandolf, Reinhard, Malesevic, Miroslav, Borst, Oliver, Gawaz, Meinrad, Langer, Harald F., Katus, Hugo, Fischer, Gunter, May, Andreas E., Kaya, Ziya, Seizer, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404136/
https://www.ncbi.nlm.nih.gov/pubmed/25894208
http://dx.doi.org/10.1371/journal.pone.0124606

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