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Low levels of taurine introgression in the current Brazilian Nelore and Gir indicine cattle populations

BACKGROUND: Nelore and Gir are the two most important indicine cattle breeds for production of beef and milk in Brazil. Historical records state that these breeds were introduced in Brazil from the Indian subcontinent, crossed to local taurine cattle in order to quickly increase the population size,...

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Autores principales: O’Brien, Ana M Perez, Höller, Daniela, Boison, Solomon A, Milanesi, Marco, Bomba, Lorenzo, Utsunomiya, Yuri T, Carvalheiro, Roberto, Neves, Haroldo HR, da Silva, Marcos VB, VanTassell, Curtis P, Sonstegard, Tad S, Mészáros, Gábor, Ajmone-Marsan, Paolo, Garcia, Fernando, Sölkner, Johann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404172/
https://www.ncbi.nlm.nih.gov/pubmed/25928250
http://dx.doi.org/10.1186/s12711-015-0109-5
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author O’Brien, Ana M Perez
Höller, Daniela
Boison, Solomon A
Milanesi, Marco
Bomba, Lorenzo
Utsunomiya, Yuri T
Carvalheiro, Roberto
Neves, Haroldo HR
da Silva, Marcos VB
VanTassell, Curtis P
Sonstegard, Tad S
Mészáros, Gábor
Ajmone-Marsan, Paolo
Garcia, Fernando
Sölkner, Johann
author_facet O’Brien, Ana M Perez
Höller, Daniela
Boison, Solomon A
Milanesi, Marco
Bomba, Lorenzo
Utsunomiya, Yuri T
Carvalheiro, Roberto
Neves, Haroldo HR
da Silva, Marcos VB
VanTassell, Curtis P
Sonstegard, Tad S
Mészáros, Gábor
Ajmone-Marsan, Paolo
Garcia, Fernando
Sölkner, Johann
author_sort O’Brien, Ana M Perez
collection PubMed
description BACKGROUND: Nelore and Gir are the two most important indicine cattle breeds for production of beef and milk in Brazil. Historical records state that these breeds were introduced in Brazil from the Indian subcontinent, crossed to local taurine cattle in order to quickly increase the population size, and then backcrossed to the original breeds to recover indicine adaptive and productive traits. Previous investigations based on sparse DNA markers detected taurine admixture in these breeds. High-density genome-wide analyses can provide high-resolution information on the genetic composition of current Nelore and Gir populations, estimate more precisely the levels and nature of taurine introgression, and shed light on their history and the strategies that were used to expand these breeds. RESULTS: We used the high-density Illumina BovineHD BeadChip with more than 777 K single nucleotide polymorphisms (SNPs) that were reduced to 697 115 after quality control filtering to investigate the structure of Nelore and Gir populations and seven other worldwide populations for comparison. Multidimensional scaling and model-based ancestry estimation clearly separated the indicine, European taurine and African taurine ancestries. The average level of taurine introgression in the autosomal genome of Nelore and Gir breeds was less than 1% but was 9% for the Brahman breed. Analyses based on the mitochondrial SNPs present in the Illumina BovineHD BeadChip did not clearly differentiate taurine and indicine haplotype groupings. CONCLUSIONS: The low level of taurine ancestry observed for both Nelore and Gir breeds confirms the historical records of crossbreeding and supports a strong directional selection against taurine haplotypes via backcrossing. Random sampling in production herds across the country and subsequent genotyping would be useful for a more complete view of the admixture levels in the commercial Nelore and Gir populations. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12711-015-0109-5) contains supplementary material, which is available to authorized users.
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spelling pubmed-44041722015-04-21 Low levels of taurine introgression in the current Brazilian Nelore and Gir indicine cattle populations O’Brien, Ana M Perez Höller, Daniela Boison, Solomon A Milanesi, Marco Bomba, Lorenzo Utsunomiya, Yuri T Carvalheiro, Roberto Neves, Haroldo HR da Silva, Marcos VB VanTassell, Curtis P Sonstegard, Tad S Mészáros, Gábor Ajmone-Marsan, Paolo Garcia, Fernando Sölkner, Johann Genet Sel Evol Research BACKGROUND: Nelore and Gir are the two most important indicine cattle breeds for production of beef and milk in Brazil. Historical records state that these breeds were introduced in Brazil from the Indian subcontinent, crossed to local taurine cattle in order to quickly increase the population size, and then backcrossed to the original breeds to recover indicine adaptive and productive traits. Previous investigations based on sparse DNA markers detected taurine admixture in these breeds. High-density genome-wide analyses can provide high-resolution information on the genetic composition of current Nelore and Gir populations, estimate more precisely the levels and nature of taurine introgression, and shed light on their history and the strategies that were used to expand these breeds. RESULTS: We used the high-density Illumina BovineHD BeadChip with more than 777 K single nucleotide polymorphisms (SNPs) that were reduced to 697 115 after quality control filtering to investigate the structure of Nelore and Gir populations and seven other worldwide populations for comparison. Multidimensional scaling and model-based ancestry estimation clearly separated the indicine, European taurine and African taurine ancestries. The average level of taurine introgression in the autosomal genome of Nelore and Gir breeds was less than 1% but was 9% for the Brahman breed. Analyses based on the mitochondrial SNPs present in the Illumina BovineHD BeadChip did not clearly differentiate taurine and indicine haplotype groupings. CONCLUSIONS: The low level of taurine ancestry observed for both Nelore and Gir breeds confirms the historical records of crossbreeding and supports a strong directional selection against taurine haplotypes via backcrossing. Random sampling in production herds across the country and subsequent genotyping would be useful for a more complete view of the admixture levels in the commercial Nelore and Gir populations. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12711-015-0109-5) contains supplementary material, which is available to authorized users. BioMed Central 2015-04-17 /pmc/articles/PMC4404172/ /pubmed/25928250 http://dx.doi.org/10.1186/s12711-015-0109-5 Text en © Perez O'Brien et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
O’Brien, Ana M Perez
Höller, Daniela
Boison, Solomon A
Milanesi, Marco
Bomba, Lorenzo
Utsunomiya, Yuri T
Carvalheiro, Roberto
Neves, Haroldo HR
da Silva, Marcos VB
VanTassell, Curtis P
Sonstegard, Tad S
Mészáros, Gábor
Ajmone-Marsan, Paolo
Garcia, Fernando
Sölkner, Johann
Low levels of taurine introgression in the current Brazilian Nelore and Gir indicine cattle populations
title Low levels of taurine introgression in the current Brazilian Nelore and Gir indicine cattle populations
title_full Low levels of taurine introgression in the current Brazilian Nelore and Gir indicine cattle populations
title_fullStr Low levels of taurine introgression in the current Brazilian Nelore and Gir indicine cattle populations
title_full_unstemmed Low levels of taurine introgression in the current Brazilian Nelore and Gir indicine cattle populations
title_short Low levels of taurine introgression in the current Brazilian Nelore and Gir indicine cattle populations
title_sort low levels of taurine introgression in the current brazilian nelore and gir indicine cattle populations
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404172/
https://www.ncbi.nlm.nih.gov/pubmed/25928250
http://dx.doi.org/10.1186/s12711-015-0109-5
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