A Double-Blinded, Randomized, Placebo-Controlled Trial to Evaluate Efficacy, Safety, and Tolerability of Single Doses of Tirasemtiv in Patients with Acetylcholine Receptor-Binding Antibody-Positive Myasthenia Gravis

Tirasemtiv is a fast skeletal troponin activator that sensitizes the sarcomere to calcium and increases muscle force following subtetanic nerve input. In an animal model of myasthenia gravis (MG), single oral doses of tirasemtiv improved muscle force and reduced fatigability. The purpose of this stu...

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Detalles Bibliográficos
Autores principales: Sanders, Donald B., Rosenfeld, Jeffrey, Dimachkie, Mazen M., Meng, Lisa, Malik, Fady I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404445/
https://www.ncbi.nlm.nih.gov/pubmed/25742919
http://dx.doi.org/10.1007/s13311-015-0345-y

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