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Membrane Environment Modulates the pK(a) Values of Transmembrane Helices

[Image: see text] In this work, we apply the recently developed constant pH molecular dynamics technique to study protonation equilibria of titratable side chains in the context of simple transmembrane (TM) helices and explore the effect of pH on their configurations in membrane bilayers. We observe...

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Detalles Bibliográficos
Autores principales:	Panahi, Afra, Brooks, Charles L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2015
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404502/ https://www.ncbi.nlm.nih.gov/pubmed/25734901 http://dx.doi.org/10.1021/acs.jpcb.5b00289

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