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TIM-3/Gal-9 interaction induces IFNγ-dependent IDO1 expression in acute myeloid leukemia blast cells

NK cells expressing TIM-3 show a marked increase in IFNγ production in response to acute myeloid leukemia (AML) blast cells that endogenously express Gal-9. Herein, we demonstrate that NK cell-mediated production of IFNγ, induced by TIM-3/Gal-9 interaction and released in bone marrow microenvironmen...

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Detalles Bibliográficos
Autores principales:	Folgiero, Valentina, Cifaldi, Loredana, Pira, Giuseppina Li, Goffredo, Bianca Maria, Vinti, Luciana, Locatelli, Franco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Letter to the Editor
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404691/ https://www.ncbi.nlm.nih.gov/pubmed/25886742 http://dx.doi.org/10.1186/s13045-015-0134-4

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