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Aβ-induced degradation of BMAL1 and CBP leads to circadian rhythm disruption in Alzheimer’s disease

BACKGROUND: Patients with Alzheimer’s disease (AD) frequently experience disruption of their circadian rhythms, but whether and how circadian clock molecules are perturbed by AD remains unknown. AD is an age-related neurological disorder and amyloid-β (Aβ) is one of major causative molecules in the...

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Detalles Bibliográficos
Autores principales:	Song, Hyundong, Moon, Minho, Choe, Han Kyoung, Han, Dong-Hee, Jang, Changhwan, Kim, Ahbin, Cho, Sehyung, Kim, Kyungjin, Mook-Jung, Inhee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404698/ https://www.ncbi.nlm.nih.gov/pubmed/25888034 http://dx.doi.org/10.1186/s13024-015-0007-x

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