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Mechanisms of chemotherapy-induced behavioral toxicities
While chemotherapeutic agents have yielded relative success in the treatment of cancer, patients are often plagued with unwanted and even debilitating side-effects from the treatment which can lead to dose reduction or even cessation of treatment. Common side effects (symptoms) of chemotherapy inclu...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404721/ https://www.ncbi.nlm.nih.gov/pubmed/25954147 http://dx.doi.org/10.3389/fnins.2015.00131 |
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author | Vichaya, Elisabeth G. Chiu, Gabriel S. Krukowski, Karen Lacourt, Tamara E. Kavelaars, Annemieke Dantzer, Robert Heijnen, Cobi J. Walker, Adam K. |
author_facet | Vichaya, Elisabeth G. Chiu, Gabriel S. Krukowski, Karen Lacourt, Tamara E. Kavelaars, Annemieke Dantzer, Robert Heijnen, Cobi J. Walker, Adam K. |
author_sort | Vichaya, Elisabeth G. |
collection | PubMed |
description | While chemotherapeutic agents have yielded relative success in the treatment of cancer, patients are often plagued with unwanted and even debilitating side-effects from the treatment which can lead to dose reduction or even cessation of treatment. Common side effects (symptoms) of chemotherapy include (i) cognitive deficiencies such as problems with attention, memory and executive functioning; (ii) fatigue and motivational deficit; and (iii) neuropathy. These symptoms often develop during treatment but can remain even after cessation of chemotherapy, severely impacting long-term quality of life. Little is known about the underlying mechanisms responsible for the development of these behavioral toxicities, however, neuroinflammation is widely considered to be one of the major mechanisms responsible for chemotherapy-induced symptoms. Here, we critically assess what is known in regards to the role of neuroinflammation in chemotherapy-induced symptoms. We also argue that, based on the available evidence, neuroinflammation is unlikely the only mechanism involved in the pathogenesis of chemotherapy-induced behavioral toxicities. We evaluate two other putative candidate mechanisms. To this end we discuss the mediating role of damage-associated molecular patterns (DAMPs) activated in response to chemotherapy-induced cellular damage. We also review the literature with respect to possible alternative mechanisms such as a chemotherapy-induced change in the bioenergetic status of the tissue involving changes in mitochondrial function in relation to chemotherapy-induced behavioral toxicities. Understanding the mechanisms that underlie the emergence of fatigue, neuropathy, and cognitive difficulties is vital to better treatment and long-term survival of cancer patients. |
format | Online Article Text |
id | pubmed-4404721 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-44047212015-05-07 Mechanisms of chemotherapy-induced behavioral toxicities Vichaya, Elisabeth G. Chiu, Gabriel S. Krukowski, Karen Lacourt, Tamara E. Kavelaars, Annemieke Dantzer, Robert Heijnen, Cobi J. Walker, Adam K. Front Neurosci Endocrinology While chemotherapeutic agents have yielded relative success in the treatment of cancer, patients are often plagued with unwanted and even debilitating side-effects from the treatment which can lead to dose reduction or even cessation of treatment. Common side effects (symptoms) of chemotherapy include (i) cognitive deficiencies such as problems with attention, memory and executive functioning; (ii) fatigue and motivational deficit; and (iii) neuropathy. These symptoms often develop during treatment but can remain even after cessation of chemotherapy, severely impacting long-term quality of life. Little is known about the underlying mechanisms responsible for the development of these behavioral toxicities, however, neuroinflammation is widely considered to be one of the major mechanisms responsible for chemotherapy-induced symptoms. Here, we critically assess what is known in regards to the role of neuroinflammation in chemotherapy-induced symptoms. We also argue that, based on the available evidence, neuroinflammation is unlikely the only mechanism involved in the pathogenesis of chemotherapy-induced behavioral toxicities. We evaluate two other putative candidate mechanisms. To this end we discuss the mediating role of damage-associated molecular patterns (DAMPs) activated in response to chemotherapy-induced cellular damage. We also review the literature with respect to possible alternative mechanisms such as a chemotherapy-induced change in the bioenergetic status of the tissue involving changes in mitochondrial function in relation to chemotherapy-induced behavioral toxicities. Understanding the mechanisms that underlie the emergence of fatigue, neuropathy, and cognitive difficulties is vital to better treatment and long-term survival of cancer patients. Frontiers Media S.A. 2015-04-21 /pmc/articles/PMC4404721/ /pubmed/25954147 http://dx.doi.org/10.3389/fnins.2015.00131 Text en Copyright © 2015 Vichaya, Chiu, Krukowski, Lacourt, Kavelaars, Dantzer, Heijnen and Walker. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Vichaya, Elisabeth G. Chiu, Gabriel S. Krukowski, Karen Lacourt, Tamara E. Kavelaars, Annemieke Dantzer, Robert Heijnen, Cobi J. Walker, Adam K. Mechanisms of chemotherapy-induced behavioral toxicities |
title | Mechanisms of chemotherapy-induced behavioral toxicities |
title_full | Mechanisms of chemotherapy-induced behavioral toxicities |
title_fullStr | Mechanisms of chemotherapy-induced behavioral toxicities |
title_full_unstemmed | Mechanisms of chemotherapy-induced behavioral toxicities |
title_short | Mechanisms of chemotherapy-induced behavioral toxicities |
title_sort | mechanisms of chemotherapy-induced behavioral toxicities |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404721/ https://www.ncbi.nlm.nih.gov/pubmed/25954147 http://dx.doi.org/10.3389/fnins.2015.00131 |
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