CTLs regulate tumor growth via cytostatic effects rather than cytotoxicity: a few T cells can influence the growth of many times more tumor cells

Cytotoxic T lymphocytes (CTLs) play a central role in antitumor immunity. We utilized B16 melanoma cells expressing the fluorescent ubiquitination-based cell cycle indicator B16-fucci implanted in host mice and adoptively transferred with pmel-1-TCR transgenic T cells to demonstrate that tumor growt...

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Detalles Bibliográficos
Autores principales: Kakimi, Kazuhiro, Matsushita, Hirokazu, Hosoi, Akihiro, Miyai, Manami, Ohara, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404888/
https://www.ncbi.nlm.nih.gov/pubmed/25949889
http://dx.doi.org/10.4161/21624011.2014.970464
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author Kakimi, Kazuhiro
Matsushita, Hirokazu
Hosoi, Akihiro
Miyai, Manami
Ohara, Osamu
author_facet Kakimi, Kazuhiro
Matsushita, Hirokazu
Hosoi, Akihiro
Miyai, Manami
Ohara, Osamu
author_sort Kakimi, Kazuhiro
collection PubMed
description Cytotoxic T lymphocytes (CTLs) play a central role in antitumor immunity. We utilized B16 melanoma cells expressing the fluorescent ubiquitination-based cell cycle indicator B16-fucci implanted in host mice and adoptively transferred with pmel-1-TCR transgenic T cells to demonstrate that tumor growth reduction is largely dependent on interferon γ-mediated cell cycle arrest rather than the cytotoxic killing of tumor cells by CTLs.
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spelling pubmed-44048882015-12-03 CTLs regulate tumor growth via cytostatic effects rather than cytotoxicity: a few T cells can influence the growth of many times more tumor cells Kakimi, Kazuhiro Matsushita, Hirokazu Hosoi, Akihiro Miyai, Manami Ohara, Osamu Oncoimmunology Author's View Cytotoxic T lymphocytes (CTLs) play a central role in antitumor immunity. We utilized B16 melanoma cells expressing the fluorescent ubiquitination-based cell cycle indicator B16-fucci implanted in host mice and adoptively transferred with pmel-1-TCR transgenic T cells to demonstrate that tumor growth reduction is largely dependent on interferon γ-mediated cell cycle arrest rather than the cytotoxic killing of tumor cells by CTLs. Taylor & Francis 2014-12-03 /pmc/articles/PMC4404888/ /pubmed/25949889 http://dx.doi.org/10.4161/21624011.2014.970464 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Kakimi, Kazuhiro
Matsushita, Hirokazu
Hosoi, Akihiro
Miyai, Manami
Ohara, Osamu
CTLs regulate tumor growth via cytostatic effects rather than cytotoxicity: a few T cells can influence the growth of many times more tumor cells
title CTLs regulate tumor growth via cytostatic effects rather than cytotoxicity: a few T cells can influence the growth of many times more tumor cells
title_full CTLs regulate tumor growth via cytostatic effects rather than cytotoxicity: a few T cells can influence the growth of many times more tumor cells
title_fullStr CTLs regulate tumor growth via cytostatic effects rather than cytotoxicity: a few T cells can influence the growth of many times more tumor cells
title_full_unstemmed CTLs regulate tumor growth via cytostatic effects rather than cytotoxicity: a few T cells can influence the growth of many times more tumor cells
title_short CTLs regulate tumor growth via cytostatic effects rather than cytotoxicity: a few T cells can influence the growth of many times more tumor cells
title_sort ctls regulate tumor growth via cytostatic effects rather than cytotoxicity: a few t cells can influence the growth of many times more tumor cells
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404888/
https://www.ncbi.nlm.nih.gov/pubmed/25949889
http://dx.doi.org/10.4161/21624011.2014.970464
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