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CTLs regulate tumor growth via cytostatic effects rather than cytotoxicity: a few T cells can influence the growth of many times more tumor cells

Cytotoxic T lymphocytes (CTLs) play a central role in antitumor immunity. We utilized B16 melanoma cells expressing the fluorescent ubiquitination-based cell cycle indicator B16-fucci implanted in host mice and adoptively transferred with pmel-1-TCR transgenic T cells to demonstrate that tumor growt...

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Detalles Bibliográficos
Autores principales:	Kakimi, Kazuhiro, Matsushita, Hirokazu, Hosoi, Akihiro, Miyai, Manami, Ohara, Osamu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2014
Materias:	Author's View
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404888/ https://www.ncbi.nlm.nih.gov/pubmed/25949889 http://dx.doi.org/10.4161/21624011.2014.970464

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