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Early handling and repeated cross-fostering have opposite effect on mouse emotionality
Early life events have a crucial role in programming the individual phenotype and exposure to traumatic experiences during infancy can increase later risk for a variety of neuropsychiatric conditions, including mood and anxiety disorders. Animal models of postnatal stress have been developed in rode...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404916/ https://www.ncbi.nlm.nih.gov/pubmed/25954170 http://dx.doi.org/10.3389/fnbeh.2015.00093 |
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author | Luchetti, Alessandra Oddi, Diego Lampis, Valentina Centofante, Eleonora Felsani, Armando Battaglia, Marco D’Amato, Francesca R. |
author_facet | Luchetti, Alessandra Oddi, Diego Lampis, Valentina Centofante, Eleonora Felsani, Armando Battaglia, Marco D’Amato, Francesca R. |
author_sort | Luchetti, Alessandra |
collection | PubMed |
description | Early life events have a crucial role in programming the individual phenotype and exposure to traumatic experiences during infancy can increase later risk for a variety of neuropsychiatric conditions, including mood and anxiety disorders. Animal models of postnatal stress have been developed in rodents to explore molecular mechanisms responsible for the observed short and long lasting neurobiological effects of such manipulations. The main aim of this study was to compare the behavioral and hormonal phenotype of young and adult animals exposed to different postnatal treatments. Outbred mice were exposed to (i) the classical Handling protocol (H: 15 min-day of separation from the mother from day 1 to 14 of life) or to (ii) a Repeated Cross-Fostering protocol (RCF: adoption of litters from day 1 to 4 of life by different dams). Handled mice received more maternal care in infancy and showed the already described reduced emotionality at adulthood. Repeated cross fostered animals did not differ for maternal care received, but showed enhanced sensitivity to separation from the mother in infancy and altered respiratory response to 6% CO(2) in breathing air in comparison with controls. Abnormal respiratory responses to hypercapnia are commonly found among humans with panic disorders (PD), and point to RCF-induced instability of the early environment as a valid developmental model for PD. The comparisons between short- and long-term effects of postnatal handling vs. RCF indicate that different types of early adversities are associated with different behavioral profiles, and evoke psychopathologies that can be distinguished according to the neurobiological systems disrupted by early-life manipulations. |
format | Online Article Text |
id | pubmed-4404916 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-44049162015-05-07 Early handling and repeated cross-fostering have opposite effect on mouse emotionality Luchetti, Alessandra Oddi, Diego Lampis, Valentina Centofante, Eleonora Felsani, Armando Battaglia, Marco D’Amato, Francesca R. Front Behav Neurosci Neuroscience Early life events have a crucial role in programming the individual phenotype and exposure to traumatic experiences during infancy can increase later risk for a variety of neuropsychiatric conditions, including mood and anxiety disorders. Animal models of postnatal stress have been developed in rodents to explore molecular mechanisms responsible for the observed short and long lasting neurobiological effects of such manipulations. The main aim of this study was to compare the behavioral and hormonal phenotype of young and adult animals exposed to different postnatal treatments. Outbred mice were exposed to (i) the classical Handling protocol (H: 15 min-day of separation from the mother from day 1 to 14 of life) or to (ii) a Repeated Cross-Fostering protocol (RCF: adoption of litters from day 1 to 4 of life by different dams). Handled mice received more maternal care in infancy and showed the already described reduced emotionality at adulthood. Repeated cross fostered animals did not differ for maternal care received, but showed enhanced sensitivity to separation from the mother in infancy and altered respiratory response to 6% CO(2) in breathing air in comparison with controls. Abnormal respiratory responses to hypercapnia are commonly found among humans with panic disorders (PD), and point to RCF-induced instability of the early environment as a valid developmental model for PD. The comparisons between short- and long-term effects of postnatal handling vs. RCF indicate that different types of early adversities are associated with different behavioral profiles, and evoke psychopathologies that can be distinguished according to the neurobiological systems disrupted by early-life manipulations. Frontiers Media S.A. 2015-04-21 /pmc/articles/PMC4404916/ /pubmed/25954170 http://dx.doi.org/10.3389/fnbeh.2015.00093 Text en Copyright © 2015 Luchetti, Oddi, Lampis, Centofante, Felsani, Battaglia and D’Amato. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Luchetti, Alessandra Oddi, Diego Lampis, Valentina Centofante, Eleonora Felsani, Armando Battaglia, Marco D’Amato, Francesca R. Early handling and repeated cross-fostering have opposite effect on mouse emotionality |
title | Early handling and repeated cross-fostering have opposite effect on mouse emotionality |
title_full | Early handling and repeated cross-fostering have opposite effect on mouse emotionality |
title_fullStr | Early handling and repeated cross-fostering have opposite effect on mouse emotionality |
title_full_unstemmed | Early handling and repeated cross-fostering have opposite effect on mouse emotionality |
title_short | Early handling and repeated cross-fostering have opposite effect on mouse emotionality |
title_sort | early handling and repeated cross-fostering have opposite effect on mouse emotionality |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404916/ https://www.ncbi.nlm.nih.gov/pubmed/25954170 http://dx.doi.org/10.3389/fnbeh.2015.00093 |
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