Paclitaxel attenuates renal interstitial fibroblast activation and interstitial fibrosis by inhibiting STAT3 signaling

Recent studies have demonstrated that paclitaxel might inhibit renal fibrosis. However, the underlying molecular mechanism remains unclear. In this study, we hypothesized that low-dose paclitaxel may block the STAT3 (signal transducer and activator of transcription 3) signaling to attenuate fibrosis...

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Detalles Bibliográficos
Autores principales: Zhang, Lei, Xu, Xuan, Yang, Ruhao, Chen, Jingwen, Wang, Shixuan, Yang, Junqin, Xiang, Xudong, He, Zhibiao, Zhao, Yu, Dong, Zheng, Zhang, Dongshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404961/
https://www.ncbi.nlm.nih.gov/pubmed/25931810
http://dx.doi.org/10.2147/DDDT.S81390

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