Sulfated Polysaccharides Isolated from Cloned Grateloupia filicina and Their Anticoagulant Activity

Sulfated polysaccharides (GSP) were isolated from the cloned Grateloupia filicina which was cultured in Jiaozhou Bay, Qingdao, China. The yield of GSP was 15.75%. The total sugar and sulfate were 40.90 and 19.89%, respectively. And the average molecular weight was 11.7 KDa. The results of neutral su...

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Detalles Bibliográficos
Autores principales: Chen, Xiaolin, Yang, Shengfeng, Wang, Jinxia, Song, Lin, Xing, Ronge, Liu, Song, Yu, Huahua, Li, Pengcheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405017/
https://www.ncbi.nlm.nih.gov/pubmed/25945340
http://dx.doi.org/10.1155/2015/612352
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author Chen, Xiaolin
Yang, Shengfeng
Wang, Jinxia
Song, Lin
Xing, Ronge
Liu, Song
Yu, Huahua
Li, Pengcheng
author_facet Chen, Xiaolin
Yang, Shengfeng
Wang, Jinxia
Song, Lin
Xing, Ronge
Liu, Song
Yu, Huahua
Li, Pengcheng
author_sort Chen, Xiaolin
collection PubMed
description Sulfated polysaccharides (GSP) were isolated from the cloned Grateloupia filicina which was cultured in Jiaozhou Bay, Qingdao, China. The yield of GSP was 15.75%. The total sugar and sulfate were 40.90 and 19.89%, respectively. And the average molecular weight was 11.7 KDa. The results of neutral sugar analysis showed that GSP was mainly sulfated polysaccharides of galactose. The experiments for activated partial thromboplastin time (APTT), prothrombin time (PT), and thrombin time (TT) anticoagulant assays in vitro indicated that GSP was a good potential anticoagulant. Therefore, this study supplied new thought for the cloned Grateloupia filicina exploitation of high-value products.
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spelling pubmed-44050172015-05-05 Sulfated Polysaccharides Isolated from Cloned Grateloupia filicina and Their Anticoagulant Activity Chen, Xiaolin Yang, Shengfeng Wang, Jinxia Song, Lin Xing, Ronge Liu, Song Yu, Huahua Li, Pengcheng Biomed Res Int Research Article Sulfated polysaccharides (GSP) were isolated from the cloned Grateloupia filicina which was cultured in Jiaozhou Bay, Qingdao, China. The yield of GSP was 15.75%. The total sugar and sulfate were 40.90 and 19.89%, respectively. And the average molecular weight was 11.7 KDa. The results of neutral sugar analysis showed that GSP was mainly sulfated polysaccharides of galactose. The experiments for activated partial thromboplastin time (APTT), prothrombin time (PT), and thrombin time (TT) anticoagulant assays in vitro indicated that GSP was a good potential anticoagulant. Therefore, this study supplied new thought for the cloned Grateloupia filicina exploitation of high-value products. Hindawi Publishing Corporation 2015 2015-04-07 /pmc/articles/PMC4405017/ /pubmed/25945340 http://dx.doi.org/10.1155/2015/612352 Text en Copyright © 2015 Xiaolin Chen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chen, Xiaolin
Yang, Shengfeng
Wang, Jinxia
Song, Lin
Xing, Ronge
Liu, Song
Yu, Huahua
Li, Pengcheng
Sulfated Polysaccharides Isolated from Cloned Grateloupia filicina and Their Anticoagulant Activity
title Sulfated Polysaccharides Isolated from Cloned Grateloupia filicina and Their Anticoagulant Activity
title_full Sulfated Polysaccharides Isolated from Cloned Grateloupia filicina and Their Anticoagulant Activity
title_fullStr Sulfated Polysaccharides Isolated from Cloned Grateloupia filicina and Their Anticoagulant Activity
title_full_unstemmed Sulfated Polysaccharides Isolated from Cloned Grateloupia filicina and Their Anticoagulant Activity
title_short Sulfated Polysaccharides Isolated from Cloned Grateloupia filicina and Their Anticoagulant Activity
title_sort sulfated polysaccharides isolated from cloned grateloupia filicina and their anticoagulant activity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405017/
https://www.ncbi.nlm.nih.gov/pubmed/25945340
http://dx.doi.org/10.1155/2015/612352
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