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Cell-of-origin chromatin organization shapes the mutational landscape of cancer
Cancer is a disease potentiated by mutations in somatic cells. Cancer mutations are not distributed uniformly along the genome. Instead, different genomic regions vary by up to 5-fold in the local density of somatic mutations(1), posing a fundamental problem for statistical methods of cancer genomic...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405175/ https://www.ncbi.nlm.nih.gov/pubmed/25693567 http://dx.doi.org/10.1038/nature14221 |