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DNA Damage Response and Spindle Assembly Checkpoint Function throughout the Cell Cycle to Ensure Genomic Integrity

Errors in replication or segregation lead to DNA damage, mutations, and aneuploidies. Consequently, cells monitor these events and delay progression through the cell cycle so repair precedes division. The DNA damage response (DDR), which monitors DNA integrity, and the spindle assembly checkpoint (S...

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Detalles Bibliográficos
Autores principales:	Lawrence, Katherine S., Chau, Thinh, Engebrecht, JoAnne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405263/ https://www.ncbi.nlm.nih.gov/pubmed/25898113 http://dx.doi.org/10.1371/journal.pgen.1005150

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