Glioblastoma adaptation traced through decline of an IDH1 clonal driver and macro-evolution of a double-minute chromosome

BACKGROUND: Glioblastoma (GBM) is the most common malignant brain cancer occurring in adults, and is associated with dismal outcome and few therapeutic options. GBM has been shown to predominantly disrupt three core pathways through somatic aberrations, rendering it ideal for precision medicine appr...

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Detalles Bibliográficos
Autores principales: Favero, F., McGranahan, N., Salm, M., Birkbak, N. J., Sanborn, J. Z., Benz, S. C., Becq, J., Peden, J. F., Kingsbury, Z., Grocok, R. J., Humphray, S., Bentley, D., Spencer-Dene, B., Gutteridge, A., Brada, M., Roger, S., Dietrich, P.-Y., Forshew, T., Gerlinger, M., Rowan, A., Stamp, G., Eklund, A. C., Szallasi, Z., Swanton, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405282/
https://www.ncbi.nlm.nih.gov/pubmed/25732040
http://dx.doi.org/10.1093/annonc/mdv127

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