Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation

Extracellular α-Synuclein has been implicated in interneuronal propagation of disease pathology in Parkinson’s Disease. How α-Synuclein is released into the extracellular space is still unclear. Here, we show that α-Synuclein is present in extracellular vesicles in the central nervous system. We fin...

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Detalles Bibliográficos
Autores principales: Kunadt, Marcel, Eckermann, Katrin, Stuendl, Anne, Gong, Jing, Russo, Belisa, Strauss, Katrin, Rai, Surya, Kügler, Sebastian, Falomir Lockhart, Lisandro, Schwalbe, Martin, Krumova, Petranka, Oliveira, Luis M. A., Bähr, Mathias, Möbius, Wiebke, Levin, Johannes, Giese, Armin, Kruse, Niels, Mollenhauer, Brit, Geiss-Friedlander, Ruth, Ludolph, Albert C., Freischmidt, Axel, Feiler, Marisa S., Danzer, Karin M., Zweckstetter, Markus, Jovin, Thomas M., Simons, Mikael, Weishaupt, Jochen H., Schneider, Anja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405286/
https://www.ncbi.nlm.nih.gov/pubmed/25778619
http://dx.doi.org/10.1007/s00401-015-1408-1

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