Inhibition of Adenylyl Cyclase Type 5 Increases Longevity and Healthful Aging through Oxidative Stress Protection

Mice with disruption of adenylyl cyclase type 5 (AC5 knockout, KO) live a third longer than littermates. The mechanism, in part, involves the MEK/ERK pathway, which in turn is related to protection against oxidative stress. The AC5 KO model also protects against diabetes, obesity, and the cardiomyop...

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Detalles Bibliográficos
Autores principales: Vatner, Stephen F., Pachon, Ronald E., Vatner, Dorothy E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405291/
https://www.ncbi.nlm.nih.gov/pubmed/25945149
http://dx.doi.org/10.1155/2015/250310

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405291/
https://www.ncbi.nlm.nih.gov/pubmed/25945149
http://dx.doi.org/10.1155/2015/250310

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