Cargando…

Inhibition of Adenylyl Cyclase Type 5 Increases Longevity and Healthful Aging through Oxidative Stress Protection

Mice with disruption of adenylyl cyclase type 5 (AC5 knockout, KO) live a third longer than littermates. The mechanism, in part, involves the MEK/ERK pathway, which in turn is related to protection against oxidative stress. The AC5 KO model also protects against diabetes, obesity, and the cardiomyop...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vatner, Stephen F., Pachon, Ronald E., Vatner, Dorothy E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2015
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405291/ https://www.ncbi.nlm.nih.gov/pubmed/25945149 http://dx.doi.org/10.1155/2015/250310

Ejemplares similares

Type 5 adenylyl cyclase disruption leads to enhanced exercise performance
por: Vatner, Dorothy E., et al.
Publicado: (2015)

‘Reduced malignancy as a mechanism for longevity in mice with adenylyl cyclase type 5 disruption’
por: De Lorenzo, Mariana S, et al.
Publicado: (2014)

Adenylyl Cyclase Type 5 Deficiency Protects Against Diet-Induced Obesity and Insulin Resistance
por: Ho, David, et al.
Publicado: (2015)

Models of longevity (Calorie Restriction and AC5 KO): Result of three bad hypotheses
por: Vatner, Stephen F., et al.
Publicado: (2012)

Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14
por: Vatner, Dorothy E., et al.
Publicado: (2018)

Vascular Stiffness in Aging and Disease
por: Vatner, Stephen F., et al.
Publicado: (2021)

New Perspectives on Plant Adenylyl Cyclases
por: Ruzvidzo, Oziniel, et al.
Publicado: (2019)

Expression and functions of adenylyl cyclases in the CNS
por: Devasani, Karan, et al.
Publicado: (2022)

Exercise enhancement by RGS14 disruption is mediated by brown adipose tissue
por: Vatner, Dorothy E., et al.
Publicado: (2023)

Adenylyl Cyclase 6 Mediates Inhibition of TNF in the Inflammatory Reflex
por: Tarnawski, Laura, et al.
Publicado: (2018)

Function of Adenylyl Cyclase in Heart: the AKAP Connection
por: Baldwin, Tanya A., et al.
Publicado: (2018)

Structural basis of adenylyl cyclase 9 activation
por: Qi, Chao, et al.
Publicado: (2022)

Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6
por: Bull Melsom, Caroline, et al.
Publicado: (2019)

On-demand male contraception via acute inhibition of soluble adenylyl cyclase
por: Balbach, Melanie, et al.
Publicado: (2023)

The evolutionary conservation of eukaryotic membrane-bound adenylyl cyclase isoforms
por: Schultz, Joachim E.
Publicado: (2022)

Activation of adenylyl cyclase in Chlamydomonas reinhardtii by adhesion and by heat
Publicado: (1993)

Soluble adenylyl cyclase is essential for proper lysosomal acidification
por: Rahman, Nawreen, et al.
Publicado: (2016)

Editorial: Adenylyl cyclase isoforms as potential drug targets
por: Brust, Tarsis F., et al.
Publicado: (2022)

Smooth Muscle Myosin Inhibition: A Novel Therapeutic Approach for Pulmonary Hypertension
por: Ho, David, et al.
Publicado: (2012)

Distinct Mechanisms of Calmodulin Binding and Regulation of Adenylyl Cyclases 1 and 8
por: Masada, Nanako, et al.
Publicado: (2012)

Adult Type 3 Adenylyl Cyclase–Deficient Mice Are Obese
por: Wang, Zhenshan, et al.
Publicado: (2009)

Spatial resolution of cAMP signaling by soluble adenylyl cyclase
por: Caldieri, Giusi, et al.
Publicado: (2016)

Prognosis and regulation of an adenylyl cyclase network in acute myeloid leukemia
por: Chen, Si-Liang, et al.
Publicado: (2020)

Gα(s), adenylyl cyclase, and their relationship to the diagnosis and treatment of depression
por: Schappi, Jeffrey M., et al.
Publicado: (2022)

Characterization of Adenylyl Cyclase Isoform 6 Residues Interacting with Forskolin
por: Bhatia, Vikram, et al.
Publicado: (2023)

Isoform Specific Regulation of Adenylyl Cyclase 5 by Gβγ
por: Yen, Yu-Chen, et al.
Publicado: (2023)

Soluble Adenylyl Cyclase Regulates Bile Salt‐Induced Apoptosis in Human Cholangiocytes
por: Chang, Jung‐Chin, et al.
Publicado: (2016)

Role of the bicarbonate-responsive soluble adenylyl cyclase in pH sensing and metabolic regulation
por: Chang, Jung-Chin, et al.
Publicado: (2014)

Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domain
por: Scheib, Ulrike, et al.
Publicado: (2018)

Adenylyl cyclase 4 does not regulate collecting duct water and sodium handling
por: Kittikulsuth, Wararat, et al.
Publicado: (2014)

Dominant regulation of interendothelial cell gap formation by calcium-inhibited type 6 adenylyl cyclase
por: Cioffi, Donna L., et al.
Publicado: (2002)

Specific inhibition of adenylyl-cyclase isoform 5 by mood stabilizers may be related to their mechanism of action
por: Mann, Liad, et al.
Publicado: (2010)

Allosteric Inhibition of Adenylyl Cyclase Type 5 by G-Protein: A Molecular Dynamics Study
por: Frezza, Elisa, et al.
Publicado: (2020)

Gα(i1) inhibition mechanism of ATP-bound adenylyl cyclase type 5
por: Narzi, Daniele, et al.
Publicado: (2021)

Selective inhibition of adenylyl cyclase subtype 1 reduces inflammatory pain in chicken of gouty arthritis
por: Liu, Ren-Hao, et al.
Publicado: (2021)

Stimulation of Mammalian G-protein-responsive Adenylyl Cyclases by Carbon Dioxide
por: Townsend, Philip D., et al.
Publicado: (2009)

Sex-Specific Role for Adenylyl Cyclase Type 7 in Alcohol Dependence
por: Desrivières, Sylvane, et al.
Publicado: (2011)

Disruption of type 3 adenylyl cyclase expression in the hypothalamus leads to obesity
por: Cao, Hong, et al.
Publicado: (2016)

Soluble Adenylyl Cyclase Is Required for Retinal Ganglion Cell and Photoreceptor Differentiation
por: Shaw, Peter X., et al.
Publicado: (2016)

Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase
por: Navarro, Gemma, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_vqv90sjrvrgmf7vtq32bkapsrp