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Sleep abnormality in neuromyelitis optica spectrum disorder

OBJECTIVES: We investigated the sleep structure of patients with neuromyelitis optica spectrum disorder (NMOSD) and the association of abnormalities with brain lesions. METHODS: This was a prospective cross-sectional study. Thirty-three patients with NMOSD and 20 matched healthy individuals were enr...

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Autores principales: Song, Yijun, Pan, Liping, Fu, Ying, Sun, Na, Li, Yu-Jing, Cai, Hao, Su, Lei, Shen, Yi, Cui, Linyang, Shi, Fu-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405292/
https://www.ncbi.nlm.nih.gov/pubmed/25918736
http://dx.doi.org/10.1212/NXI.0000000000000094
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author Song, Yijun
Pan, Liping
Fu, Ying
Sun, Na
Li, Yu-Jing
Cai, Hao
Su, Lei
Shen, Yi
Cui, Linyang
Shi, Fu-Dong
author_facet Song, Yijun
Pan, Liping
Fu, Ying
Sun, Na
Li, Yu-Jing
Cai, Hao
Su, Lei
Shen, Yi
Cui, Linyang
Shi, Fu-Dong
author_sort Song, Yijun
collection PubMed
description OBJECTIVES: We investigated the sleep structure of patients with neuromyelitis optica spectrum disorder (NMOSD) and the association of abnormalities with brain lesions. METHODS: This was a prospective cross-sectional study. Thirty-three patients with NMOSD and 20 matched healthy individuals were enrolled. Demographic and clinical characteristics of patients were collected. Questionnaires were used to assess quality of sleep, daytime sleepiness, fatigue, and depression. Nocturnal polysomnography was performed. RESULTS: Compared with healthy controls, patients with NMOSD had decreases in sleep efficiency (7%; p = 0.0341), non-REM sleep N3 (12%; p < 0.0001), and arousal index (6; p = 0.0138). REM sleep increased by 4% (p = 0.0423). There were correlations between arousal index and REM% or Epworth Sleepiness Scale (r = −0.0145; p = 0.0386, respectively). Six patients with NMOSD (18%, 5 without infratentorial lesions and 1 with infratentorial lesions) had a hypopnea index >5, and all of those with sleep apnea had predominantly the peripheral type. The periodic leg movement (PLM) index was higher in patients with NMOSD than in healthy controls (20 vs 2, p = 0.0457). Surprisingly, 77% of the patients with PLM manifested infratentorial lesions. CONCLUSIONS: Sleep architecture was markedly disrupted in patients with NMOSD. Surveillance of nocturnal symptoms and adequate symptomatic control are expected to improve the quality of life of patients with NMOSD.
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spelling pubmed-44052922015-04-27 Sleep abnormality in neuromyelitis optica spectrum disorder Song, Yijun Pan, Liping Fu, Ying Sun, Na Li, Yu-Jing Cai, Hao Su, Lei Shen, Yi Cui, Linyang Shi, Fu-Dong Neurol Neuroimmunol Neuroinflamm Article OBJECTIVES: We investigated the sleep structure of patients with neuromyelitis optica spectrum disorder (NMOSD) and the association of abnormalities with brain lesions. METHODS: This was a prospective cross-sectional study. Thirty-three patients with NMOSD and 20 matched healthy individuals were enrolled. Demographic and clinical characteristics of patients were collected. Questionnaires were used to assess quality of sleep, daytime sleepiness, fatigue, and depression. Nocturnal polysomnography was performed. RESULTS: Compared with healthy controls, patients with NMOSD had decreases in sleep efficiency (7%; p = 0.0341), non-REM sleep N3 (12%; p < 0.0001), and arousal index (6; p = 0.0138). REM sleep increased by 4% (p = 0.0423). There were correlations between arousal index and REM% or Epworth Sleepiness Scale (r = −0.0145; p = 0.0386, respectively). Six patients with NMOSD (18%, 5 without infratentorial lesions and 1 with infratentorial lesions) had a hypopnea index >5, and all of those with sleep apnea had predominantly the peripheral type. The periodic leg movement (PLM) index was higher in patients with NMOSD than in healthy controls (20 vs 2, p = 0.0457). Surprisingly, 77% of the patients with PLM manifested infratentorial lesions. CONCLUSIONS: Sleep architecture was markedly disrupted in patients with NMOSD. Surveillance of nocturnal symptoms and adequate symptomatic control are expected to improve the quality of life of patients with NMOSD. Lippincott Williams & Wilkins 2015-04-16 /pmc/articles/PMC4405292/ /pubmed/25918736 http://dx.doi.org/10.1212/NXI.0000000000000094 Text en © 2015 American Academy of Neurology This is an open access article distributed under the terms of the Creative Commons Attribution-Noncommercial No Derivative 3.0 License, which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially.
spellingShingle Article
Song, Yijun
Pan, Liping
Fu, Ying
Sun, Na
Li, Yu-Jing
Cai, Hao
Su, Lei
Shen, Yi
Cui, Linyang
Shi, Fu-Dong
Sleep abnormality in neuromyelitis optica spectrum disorder
title Sleep abnormality in neuromyelitis optica spectrum disorder
title_full Sleep abnormality in neuromyelitis optica spectrum disorder
title_fullStr Sleep abnormality in neuromyelitis optica spectrum disorder
title_full_unstemmed Sleep abnormality in neuromyelitis optica spectrum disorder
title_short Sleep abnormality in neuromyelitis optica spectrum disorder
title_sort sleep abnormality in neuromyelitis optica spectrum disorder
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405292/
https://www.ncbi.nlm.nih.gov/pubmed/25918736
http://dx.doi.org/10.1212/NXI.0000000000000094
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