Antibacterial and Antiproliferative Activities of Plumericin, an Iridoid Isolated from Momordica charantia Vine

Plumericin, an iridoid lactone, was isolated with relatively high yield from Momordica charantia vine using the supercritical fluid extraction (SFE) and the separation box (Sepbox) comprising dual combination of high-performance liquid chromatography and solid phase extraction. This compound showed...

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Autores principales: Saengsai, Jutamas, Kongtunjanphuk, Sumonthip, Yoswatthana, Nuttawan, Kummalue, Tanawan, Jiratchariyakul, Weena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405293/
https://www.ncbi.nlm.nih.gov/pubmed/25945113
http://dx.doi.org/10.1155/2015/823178
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author Saengsai, Jutamas
Kongtunjanphuk, Sumonthip
Yoswatthana, Nuttawan
Kummalue, Tanawan
Jiratchariyakul, Weena
author_facet Saengsai, Jutamas
Kongtunjanphuk, Sumonthip
Yoswatthana, Nuttawan
Kummalue, Tanawan
Jiratchariyakul, Weena
author_sort Saengsai, Jutamas
collection PubMed
description Plumericin, an iridoid lactone, was isolated with relatively high yield from Momordica charantia vine using the supercritical fluid extraction (SFE) and the separation box (Sepbox) comprising dual combination of high-performance liquid chromatography and solid phase extraction. This compound showed antibacterial activity against Enterococcus faecalis and Bacillus subtilis with minimum inhibitory concentration (MIC) values better than cloxacillin. Plumericin potently inhibited proliferation of two leukemic cancer cell lines: they were acute and chronic leukemic cancer cell lines, NB4 and K562, with the effective doses (ED(50)) of 4.35 ± 0.21 and 5.58 ± 0.35 μg/mL, respectively. In addition, the mechanism of growth inhibition in both cell lines was induced by apoptosis, together with G2/M arrest in K562 cells.
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spelling pubmed-44052932015-05-05 Antibacterial and Antiproliferative Activities of Plumericin, an Iridoid Isolated from Momordica charantia Vine Saengsai, Jutamas Kongtunjanphuk, Sumonthip Yoswatthana, Nuttawan Kummalue, Tanawan Jiratchariyakul, Weena Evid Based Complement Alternat Med Research Article Plumericin, an iridoid lactone, was isolated with relatively high yield from Momordica charantia vine using the supercritical fluid extraction (SFE) and the separation box (Sepbox) comprising dual combination of high-performance liquid chromatography and solid phase extraction. This compound showed antibacterial activity against Enterococcus faecalis and Bacillus subtilis with minimum inhibitory concentration (MIC) values better than cloxacillin. Plumericin potently inhibited proliferation of two leukemic cancer cell lines: they were acute and chronic leukemic cancer cell lines, NB4 and K562, with the effective doses (ED(50)) of 4.35 ± 0.21 and 5.58 ± 0.35 μg/mL, respectively. In addition, the mechanism of growth inhibition in both cell lines was induced by apoptosis, together with G2/M arrest in K562 cells. Hindawi Publishing Corporation 2015 2015-04-07 /pmc/articles/PMC4405293/ /pubmed/25945113 http://dx.doi.org/10.1155/2015/823178 Text en Copyright © 2015 Jutamas Saengsai et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Saengsai, Jutamas
Kongtunjanphuk, Sumonthip
Yoswatthana, Nuttawan
Kummalue, Tanawan
Jiratchariyakul, Weena
Antibacterial and Antiproliferative Activities of Plumericin, an Iridoid Isolated from Momordica charantia Vine
title Antibacterial and Antiproliferative Activities of Plumericin, an Iridoid Isolated from Momordica charantia Vine
title_full Antibacterial and Antiproliferative Activities of Plumericin, an Iridoid Isolated from Momordica charantia Vine
title_fullStr Antibacterial and Antiproliferative Activities of Plumericin, an Iridoid Isolated from Momordica charantia Vine
title_full_unstemmed Antibacterial and Antiproliferative Activities of Plumericin, an Iridoid Isolated from Momordica charantia Vine
title_short Antibacterial and Antiproliferative Activities of Plumericin, an Iridoid Isolated from Momordica charantia Vine
title_sort antibacterial and antiproliferative activities of plumericin, an iridoid isolated from momordica charantia vine
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405293/
https://www.ncbi.nlm.nih.gov/pubmed/25945113
http://dx.doi.org/10.1155/2015/823178
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