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Finding the elusive and causative autoantibody: An atypical case of autoimmune hemolytic anemia

An isolated IgA-mediated autoimmune hemolytic anemia can present a diagnostic challenge. When a routine direct antiglobulin test (DAT) is negative but clinical suspicion remains high, further testing with monospecific antisera should be performed. As with IgG-mediated WAIHA, steroids are first-line...

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Detalles Bibliográficos
Autores principales: Fetzko, Stephanie, Ahmed, Asra, Cooling, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405306/
https://www.ncbi.nlm.nih.gov/pubmed/25914813
http://dx.doi.org/10.1002/ccr3.203
Descripción
Sumario:An isolated IgA-mediated autoimmune hemolytic anemia can present a diagnostic challenge. When a routine direct antiglobulin test (DAT) is negative but clinical suspicion remains high, further testing with monospecific antisera should be performed. As with IgG-mediated WAIHA, steroids are first-line treatment, though splenectomy is often required to achieve a durable treatment response.