M. leprae components induce nerve damage by complement activation: identification of lipoarabinomannan as the dominant complement activator

Peripheral nerve damage is the hallmark of leprosy pathology but its etiology is unclear. We previously identified the membrane attack complex (MAC) of the complement system as a key determinant of post-traumatic nerve damage and demonstrated that its inhibition is neuroprotective. Here, we determin...

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Detalles Bibliográficos
Autores principales: Bahia El Idrissi, Nawal, Das, Pranab K., Fluiter, Kees, Rosa, Patricia S., Vreijling, Jeroen, Troost, Dirk, Morgan, B. Paul, Baas, Frank, Ramaglia, Valeria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405335/
https://www.ncbi.nlm.nih.gov/pubmed/25772973
http://dx.doi.org/10.1007/s00401-015-1404-5

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