Effect of TIM-3 Blockade on the Immunophenotype and Cytokine Profile of Murine Uterine NK Cells

NK cells are the most abundant lymphocyte population in the feto-maternal interface during gestation. The uterine NK cells (uNK) are transient, have a unique immunophenotype and produce a number of cytokines. These cytokines play an important role in establishment and maintenance of vascular remodel...

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Autores principales: Tripathi, Sudipta, Chabtini, Lola, Dakle, Pranal J., Smith, Brian, Akiba, Hisaya, Yagita, Hideo, Guleria, Indira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405344/
https://www.ncbi.nlm.nih.gov/pubmed/25897749
http://dx.doi.org/10.1371/journal.pone.0123439
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author Tripathi, Sudipta
Chabtini, Lola
Dakle, Pranal J.
Smith, Brian
Akiba, Hisaya
Yagita, Hideo
Guleria, Indira
author_facet Tripathi, Sudipta
Chabtini, Lola
Dakle, Pranal J.
Smith, Brian
Akiba, Hisaya
Yagita, Hideo
Guleria, Indira
author_sort Tripathi, Sudipta
collection PubMed
description NK cells are the most abundant lymphocyte population in the feto-maternal interface during gestation. The uterine NK cells (uNK) are transient, have a unique immunophenotype and produce a number of cytokines. These cytokines play an important role in establishment and maintenance of vascular remodeling and tolerance associated with successful pregnancy. The uNK cells also express TIM-3 during gestation and blockade of TIM-3 expression results in fetal loss in mice. In this study we determined the effect of TIM-3 blockade on uNK cells. Specifically we observed surface receptor phenotype and cytokine production by uNK cells following TIM-3 blockade. Our results show that TIM-3 plays a role in regulating the uNK cells and contributes to the maintenance of tolerance at the feto-maternal interface.
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spelling pubmed-44053442015-05-07 Effect of TIM-3 Blockade on the Immunophenotype and Cytokine Profile of Murine Uterine NK Cells Tripathi, Sudipta Chabtini, Lola Dakle, Pranal J. Smith, Brian Akiba, Hisaya Yagita, Hideo Guleria, Indira PLoS One Research Article NK cells are the most abundant lymphocyte population in the feto-maternal interface during gestation. The uterine NK cells (uNK) are transient, have a unique immunophenotype and produce a number of cytokines. These cytokines play an important role in establishment and maintenance of vascular remodeling and tolerance associated with successful pregnancy. The uNK cells also express TIM-3 during gestation and blockade of TIM-3 expression results in fetal loss in mice. In this study we determined the effect of TIM-3 blockade on uNK cells. Specifically we observed surface receptor phenotype and cytokine production by uNK cells following TIM-3 blockade. Our results show that TIM-3 plays a role in regulating the uNK cells and contributes to the maintenance of tolerance at the feto-maternal interface. Public Library of Science 2015-04-21 /pmc/articles/PMC4405344/ /pubmed/25897749 http://dx.doi.org/10.1371/journal.pone.0123439 Text en © 2015 Tripathi et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Tripathi, Sudipta
Chabtini, Lola
Dakle, Pranal J.
Smith, Brian
Akiba, Hisaya
Yagita, Hideo
Guleria, Indira
Effect of TIM-3 Blockade on the Immunophenotype and Cytokine Profile of Murine Uterine NK Cells
title Effect of TIM-3 Blockade on the Immunophenotype and Cytokine Profile of Murine Uterine NK Cells
title_full Effect of TIM-3 Blockade on the Immunophenotype and Cytokine Profile of Murine Uterine NK Cells
title_fullStr Effect of TIM-3 Blockade on the Immunophenotype and Cytokine Profile of Murine Uterine NK Cells
title_full_unstemmed Effect of TIM-3 Blockade on the Immunophenotype and Cytokine Profile of Murine Uterine NK Cells
title_short Effect of TIM-3 Blockade on the Immunophenotype and Cytokine Profile of Murine Uterine NK Cells
title_sort effect of tim-3 blockade on the immunophenotype and cytokine profile of murine uterine nk cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405344/
https://www.ncbi.nlm.nih.gov/pubmed/25897749
http://dx.doi.org/10.1371/journal.pone.0123439
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