Cargando…

Type I Interferon-Mediated Skewing of the Serotonin Synthesis Is Associated with Severe Disease in Systemic Lupus Erythematosus

Serotonin, a highly pro-inflammatory molecule released by activated platelets, is formed by tryptophan. Tryptophan is also needed in the production of kynurenine, a process mediated by the type I interferon (IFN)-regulated rate-limiting enzyme indoleamine 2,3-dioxygenase (IDO). The aim of this study...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lood, Christian, Tydén, Helena, Gullstrand, Birgitta, Klint, Cecilia, Wenglén, Christina, Nielsen, Christoffer T., Heegaard, Niels H. H., Jönsen, Andreas, Kahn, Robin, Bengtsson, Anders A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405357/ https://www.ncbi.nlm.nih.gov/pubmed/25897671 http://dx.doi.org/10.1371/journal.pone.0125109

Ejemplares similares

Endothelial dysfunction is associated with activation of the type I interferon system and platelets in patients with systemic lupus erythematosus
por: Tydén, Helena, et al.
Publicado: (2017)

Platelet Activation and Anti-Phospholipid Antibodies Collaborate in the Activation of the Complement System on Platelets in Systemic Lupus Erythematosus
por: Lood, Christian, et al.
Publicado: (2014)

Low plasma concentrations of apolipoprotein M are associated with disease activity and endothelial dysfunction in systemic lupus erythematosus
por: Tydén, Helena, et al.
Publicado: (2019)

Low Intra-Individual Variation in Mean Platelet Volume Over Time in Systemic Lupus Erythematosus
por: Wirestam, Lina, et al.
Publicado: (2021)

Plasma levels of galectin-3-binding protein reflect type I interferon activity and are increased in patients with systemic lupus erythematosus
por: Nielsen, Christoffer T, et al.
Publicado: (2014)

Enrichment of Complement, Immunoglobulins, and Autoantibody Targets in the Proteome of Platelets from Patients with Systemic Lupus Erythematosus
por: Linge, Carl Petrus, et al.
Publicado: (2022)

Neutrophil FcγRIIA availability is associated with disease activity in systemic lupus erythematosus
por: Bengtsson, Anders A., et al.
Publicado: (2020)

Plasma C4d as marker for lupus nephritis in systemic lupus erythematosus
por: Martin, Myriam, et al.
Publicado: (2017)

The assessment of serum-mediated phagocytosis of necrotic material by polymorphonuclear leukocytes to diagnose and predict the clinical features of systemic lupus erythematosus: an observational longitudinal study
por: Compagno, Michele, et al.
Publicado: (2016)

Protein synthesis of the pro-inflammatory S100A8/A9 complex in plasmacytoid dendritic cells and cell surface S100A8/A9 on leukocyte subpopulations in systemic lupus erythematosus
por: Lood, Christian, et al.
Publicado: (2011)

Degradation of neutrophil extracellular traps co-varies with disease activity in patients with systemic lupus erythematosus
por: Leffler, Jonatan, et al.
Publicado: (2013)

Plasma and cerebrospinal fluid neurofilament light concentrations reflect neuronal damage in systemic lupus Erythematosus
por: Zervides, Kristoffer A., et al.
Publicado: (2022)

Comparison of Surrogate Markers of the Type I Interferon Response and Their Ability to Mirror Disease Activity in Systemic Lupus Erythematosus
por: Enocsson, Helena, et al.
Publicado: (2021)

Serum S100A8/A9 concentrations are associated with neuropsychiatric involvement in systemic lupus erythematosus: a cross-sectional study
por: Zervides, Kristoffer A., et al.
Publicado: (2022)

C-Reactive Protein Levels in Systemic Lupus Erythematosus Are Modulated by the Interferon Gene Signature and CRP Gene Polymorphism rs1205
por: Enocsson, Helena, et al.
Publicado: (2021)

Neutrophil and lymphocyte counts are associated with different immunopathological mechanisms in systemic lupus erythematosus
por: Han, Bobby Kwanghoon, et al.
Publicado: (2020)

A subset of patients with systemic lupus erythematosus fails to degrade DNA from multiple clinically relevant sources
por: Leffler, Jonatan, et al.
Publicado: (2015)

Low production of reactive oxygen species in granulocytes is associated with organ damage in systemic lupus erythematosus
por: Bengtsson, Anders A, et al.
Publicado: (2014)

Distinct proteome pathology of circulating microparticles in systemic lupus erythematosus
por: Østergaard, Ole, et al.
Publicado: (2017)

Children with oligoarticular juvenile idiopathic arthritis have skewed synovial monocyte polarization pattern with functional impairment—a distinct inflammatory pattern for oligoarticular juvenile arthritis
por: Schmidt, Tobias, et al.
Publicado: (2020)

A review of studies of the proteomes of circulating microparticles: key roles for galectin-3-binding protein-expressing microparticles in vascular diseases and systemic lupus erythematosus
por: Nielsen, Christoffer T., et al.
Publicado: (2017)

Plasma concentrations of Gas6 and sAxl correlate with disease activity in systemic lupus erythematosus
por: Ekman, Carl, et al.
Publicado: (2011)

Contact activation products are new potential biomarkers to evaluate the risk of thrombotic events in systemic lupus erythematosus
por: Bäck, Jennie, et al.
Publicado: (2013)

Sex differences in clinical presentation of systemic lupus erythematosus
por: Ramírez Sepúlveda, Jorge I., et al.
Publicado: (2019)

Autoantibody and Cytokine Profiles during Treatment with Belimumab in Patients with Systemic Lupus Erythematosus
por: Parodis, Ioannis, et al.
Publicado: (2020)

Contributions of de novo variants to systemic lupus erythematosus
por: Almlöf, Jonas Carlsson, et al.
Publicado: (2020)

Adverse Pregnancy Outcomes after Multi-Professional Follow-Up of Women with Systemic Lupus Erythematosus: An Observational Study from a Single Centre in Sweden
por: Saleh, Muna, et al.
Publicado: (2020)

Mismatch between circulating cytokines and spontaneous cytokine production by leukocytes in hyperinflammatory COVID-19
por: Kahn, Robin, et al.
Publicado: (2020)

Low-density granulocytes are related to shorter pregnancy duration but not to interferon alpha protein blood levels in systemic lupus erythematosus
por: Torell, Agnes, et al.
Publicado: (2023)

Interferon Alpha in Systemic Lupus Erythematosus
por: Niewold, Timothy B., et al.
Publicado: (2010)

Complement deposition, C4d, on platelets is associated with vascular events in systemic lupus erythematosus
por: Svenungsson, Elisabet, et al.
Publicado: (2020)

Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis
por: Wu, Jun, et al.
Publicado: (2011)

MRI BrainAGE demonstrates increased brain aging in systemic lupus erythematosus patients
por: Kuchcinski, Grégory, et al.
Publicado: (2023)

Transcriptome reprogramming and myeloid skewing in haematopoietic stem and progenitor cells in systemic lupus erythematosus
por: Grigoriou, Maria, et al.
Publicado: (2020)

Neutrophils - a complex story in the pathogenesis of systemic lupus erythematosus
por: Lood, Christian, et al.
Publicado: (2014)

Sources of Pathogenic Nucleic Acids in Systemic Lupus Erythematosus
por: Mustelin, Tomas, et al.
Publicado: (2019)

Interferon targeted therapies in systemic lupus erythematosus
por: Misra, Durga Prasanna, et al.
Publicado: (2017)

Metabolic Profiling of Systemic Lupus Erythematosus and Comparison with Primary Sjögren’s Syndrome and Systemic Sclerosis
por: Bengtsson, Anders A., et al.
Publicado: (2016)

Synovial fluid neutrophils in oligoarticular juvenile idiopathic arthritis have an altered phenotype and impaired effector functions
por: Arve-Butler, Sabine, et al.
Publicado: (2021)

Analysis of HLA DR, HLA DQ, C4A, FcγRIIa, FcγRIIIa, MBL, and IL-1Ra allelic variants in Caucasian systemic lupus erythematosus patients suggests an effect of the combined FcγRIIa R/R and IL-1Ra 2/2 genotypes on disease susceptibility
por: Jönsen, Andreas, et al.
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_h4gfd078kqolhmjm7q5ju2ov8f