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Central Nervous System Metastasis in Epithelial Ovarian Carcinoma: A Case Report and Literature Review

Objective: To report involvement of the central nervous system (CNS) following epithelial ovarian cancer is rare. Advances in management of ovarian cancer by use of primary surgery including abdominal hysterectomy, bilateral salpingo’oophorectomy should attain as complete a cytoreduction as possible...

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Autores principales: Fakour, Fereshteh, Hajizadeh Fallah, Hadi, Khajeh Jahromi, Sina, Porteghali, Parham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405516/
https://www.ncbi.nlm.nih.gov/pubmed/25904967
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author Fakour, Fereshteh
Hajizadeh Fallah, Hadi
Khajeh Jahromi, Sina
Porteghali, Parham
author_facet Fakour, Fereshteh
Hajizadeh Fallah, Hadi
Khajeh Jahromi, Sina
Porteghali, Parham
author_sort Fakour, Fereshteh
collection PubMed
description Objective: To report involvement of the central nervous system (CNS) following epithelial ovarian cancer is rare. Advances in management of ovarian cancer by use of primary surgery including abdominal hysterectomy, bilateral salpingo’oophorectomy should attain as complete a cytoreduction as possible and effective platinum-based chemotherapy have prolonged survival. Case report: We present a case involving a 35-year-old Iranian woman diagnosed and treated for primary ovarian cancer in 2002. She underwent optimal cytoreductive surgery and chemotherapy treatment. Eight months after the initiation of therapy, multiple brain metastases without intraperitoneal lesions were found and treated with combination chemotherapy and whole brain radiotherapy (WBRT), without evidence of recurrent disease. The patient died from disease in December 2005. Conclusion: In a patient suffering from neoplasm that rarely metastasizes to CNS, a careful clinical examination and proper therapeutic approach including chemotherapy may lead to prolong survival.
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spelling pubmed-44055162015-04-22 Central Nervous System Metastasis in Epithelial Ovarian Carcinoma: A Case Report and Literature Review Fakour, Fereshteh Hajizadeh Fallah, Hadi Khajeh Jahromi, Sina Porteghali, Parham J Family Reprod Health Case Report Objective: To report involvement of the central nervous system (CNS) following epithelial ovarian cancer is rare. Advances in management of ovarian cancer by use of primary surgery including abdominal hysterectomy, bilateral salpingo’oophorectomy should attain as complete a cytoreduction as possible and effective platinum-based chemotherapy have prolonged survival. Case report: We present a case involving a 35-year-old Iranian woman diagnosed and treated for primary ovarian cancer in 2002. She underwent optimal cytoreductive surgery and chemotherapy treatment. Eight months after the initiation of therapy, multiple brain metastases without intraperitoneal lesions were found and treated with combination chemotherapy and whole brain radiotherapy (WBRT), without evidence of recurrent disease. The patient died from disease in December 2005. Conclusion: In a patient suffering from neoplasm that rarely metastasizes to CNS, a careful clinical examination and proper therapeutic approach including chemotherapy may lead to prolong survival. Tehran University of Medical Sciences 2015-03 /pmc/articles/PMC4405516/ /pubmed/25904967 Text en Copyright © Vali-e-Asr Reproductive Health Research Center, Tehran University of Medical Sciences This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Fakour, Fereshteh
Hajizadeh Fallah, Hadi
Khajeh Jahromi, Sina
Porteghali, Parham
Central Nervous System Metastasis in Epithelial Ovarian Carcinoma: A Case Report and Literature Review
title Central Nervous System Metastasis in Epithelial Ovarian Carcinoma: A Case Report and Literature Review
title_full Central Nervous System Metastasis in Epithelial Ovarian Carcinoma: A Case Report and Literature Review
title_fullStr Central Nervous System Metastasis in Epithelial Ovarian Carcinoma: A Case Report and Literature Review
title_full_unstemmed Central Nervous System Metastasis in Epithelial Ovarian Carcinoma: A Case Report and Literature Review
title_short Central Nervous System Metastasis in Epithelial Ovarian Carcinoma: A Case Report and Literature Review
title_sort central nervous system metastasis in epithelial ovarian carcinoma: a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405516/
https://www.ncbi.nlm.nih.gov/pubmed/25904967
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