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High Proportion of HIV Serodiscordance among HIV-Affected Married Couples in Northern Vietnam

INTRODUCTION: Little is known about the state of HIV transmission among married couples in Vietnam. This study aims to clarify HIV serostatus in this group and elucidate risk factors for intra-marital HIV transmission. METHODS: In 2012, we enrolled a group of HIV-positive married men registered at t...

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Autores principales: Sawada, Ikumi, Tanuma, Junko, Do, Cuong Duy, Doan, Tra Thu, Luu, Quynh Phuong, Nguyen, Lan Anh Thi, Vu, Tuong Van Thi, Nguyen, Tuan Quang, Tsuchiya, Naho, Shiino, Teiichiro, Yoshida, Lay-Myint, Pham, Thanh Thuy Thi, Ariyoshi, Koya, Oka, Shinichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405585/
https://www.ncbi.nlm.nih.gov/pubmed/25898138
http://dx.doi.org/10.1371/journal.pone.0125299
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author Sawada, Ikumi
Tanuma, Junko
Do, Cuong Duy
Doan, Tra Thu
Luu, Quynh Phuong
Nguyen, Lan Anh Thi
Vu, Tuong Van Thi
Nguyen, Tuan Quang
Tsuchiya, Naho
Shiino, Teiichiro
Yoshida, Lay-Myint
Pham, Thanh Thuy Thi
Ariyoshi, Koya
Oka, Shinichi
author_facet Sawada, Ikumi
Tanuma, Junko
Do, Cuong Duy
Doan, Tra Thu
Luu, Quynh Phuong
Nguyen, Lan Anh Thi
Vu, Tuong Van Thi
Nguyen, Tuan Quang
Tsuchiya, Naho
Shiino, Teiichiro
Yoshida, Lay-Myint
Pham, Thanh Thuy Thi
Ariyoshi, Koya
Oka, Shinichi
author_sort Sawada, Ikumi
collection PubMed
description INTRODUCTION: Little is known about the state of HIV transmission among married couples in Vietnam. This study aims to clarify HIV serostatus in this group and elucidate risk factors for intra-marital HIV transmission. METHODS: In 2012, we enrolled a group of HIV-positive married men registered at the HIV outpatient clinic of a referral hospital in northern Vietnam, along with their wives. Sociodemographic, behavioural and clinical data were collected from men and wives. HIV serodiscordant couples were followed until March 2014 to determine seroconversion rate. A phylogenetic analysis was performed based on env V3 sequence to detail cluster formation among men. RESULTS: Of the 163 HIV-positive men enrolled in the study, 101 (62.0%) had wives testing HIV-negative. Half of men reported injecting drug use (IDU) as a likely transmission route. Couples reported a high incidence of unprotected sexual intercourse prior to diagnosis; the median (inter quartile range) was 4 (4–8) times per month. Only 17 couples (10.4%) reported using condoms during at least half these instances. Multivariable analysis revealed IDU history among men was independently associated with HIV-negative wives (adjusted OR 0.31; 95% CI 0.10–0.95, p=0.041). Phylogenetic analysis of 80 samples indicated CRF01_AE. Of these, 69 (86.3%) clustered with IDU-associated viruses from Vietnam. No HIV seroconversion was identified during a follow-up of 61 serodiscordant couples, with 126.5 person-years of observation during which HIV-infected men were on antiretroviral drug therapy (ART). CONCLUSION: High HIV serodiscordance was observed among HIV-affected married couples in northern Vietnam. A large number of at-risk wives therefore remain HIV-negative and can be protected with measures including proper use of ART if couples are made aware of the serodiscordance through screening.
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spelling pubmed-44055852015-05-07 High Proportion of HIV Serodiscordance among HIV-Affected Married Couples in Northern Vietnam Sawada, Ikumi Tanuma, Junko Do, Cuong Duy Doan, Tra Thu Luu, Quynh Phuong Nguyen, Lan Anh Thi Vu, Tuong Van Thi Nguyen, Tuan Quang Tsuchiya, Naho Shiino, Teiichiro Yoshida, Lay-Myint Pham, Thanh Thuy Thi Ariyoshi, Koya Oka, Shinichi PLoS One Research Article INTRODUCTION: Little is known about the state of HIV transmission among married couples in Vietnam. This study aims to clarify HIV serostatus in this group and elucidate risk factors for intra-marital HIV transmission. METHODS: In 2012, we enrolled a group of HIV-positive married men registered at the HIV outpatient clinic of a referral hospital in northern Vietnam, along with their wives. Sociodemographic, behavioural and clinical data were collected from men and wives. HIV serodiscordant couples were followed until March 2014 to determine seroconversion rate. A phylogenetic analysis was performed based on env V3 sequence to detail cluster formation among men. RESULTS: Of the 163 HIV-positive men enrolled in the study, 101 (62.0%) had wives testing HIV-negative. Half of men reported injecting drug use (IDU) as a likely transmission route. Couples reported a high incidence of unprotected sexual intercourse prior to diagnosis; the median (inter quartile range) was 4 (4–8) times per month. Only 17 couples (10.4%) reported using condoms during at least half these instances. Multivariable analysis revealed IDU history among men was independently associated with HIV-negative wives (adjusted OR 0.31; 95% CI 0.10–0.95, p=0.041). Phylogenetic analysis of 80 samples indicated CRF01_AE. Of these, 69 (86.3%) clustered with IDU-associated viruses from Vietnam. No HIV seroconversion was identified during a follow-up of 61 serodiscordant couples, with 126.5 person-years of observation during which HIV-infected men were on antiretroviral drug therapy (ART). CONCLUSION: High HIV serodiscordance was observed among HIV-affected married couples in northern Vietnam. A large number of at-risk wives therefore remain HIV-negative and can be protected with measures including proper use of ART if couples are made aware of the serodiscordance through screening. Public Library of Science 2015-04-21 /pmc/articles/PMC4405585/ /pubmed/25898138 http://dx.doi.org/10.1371/journal.pone.0125299 Text en © 2015 Sawada et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Sawada, Ikumi
Tanuma, Junko
Do, Cuong Duy
Doan, Tra Thu
Luu, Quynh Phuong
Nguyen, Lan Anh Thi
Vu, Tuong Van Thi
Nguyen, Tuan Quang
Tsuchiya, Naho
Shiino, Teiichiro
Yoshida, Lay-Myint
Pham, Thanh Thuy Thi
Ariyoshi, Koya
Oka, Shinichi
High Proportion of HIV Serodiscordance among HIV-Affected Married Couples in Northern Vietnam
title High Proportion of HIV Serodiscordance among HIV-Affected Married Couples in Northern Vietnam
title_full High Proportion of HIV Serodiscordance among HIV-Affected Married Couples in Northern Vietnam
title_fullStr High Proportion of HIV Serodiscordance among HIV-Affected Married Couples in Northern Vietnam
title_full_unstemmed High Proportion of HIV Serodiscordance among HIV-Affected Married Couples in Northern Vietnam
title_short High Proportion of HIV Serodiscordance among HIV-Affected Married Couples in Northern Vietnam
title_sort high proportion of hiv serodiscordance among hiv-affected married couples in northern vietnam
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405585/
https://www.ncbi.nlm.nih.gov/pubmed/25898138
http://dx.doi.org/10.1371/journal.pone.0125299
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