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Viral coinfection in acute respiratory infection in Mexican children treated by the emergency service: A cross-sectional study
BACKGROUND: Acute respiratory infections (ARIs) cause illness. Children under five years of age are highly vulnerable to these infections. Viral coinfection or multiple viral infection is a variable that can have a significant impact on the evolution of these diseases. METHODS: This cross-sectional...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405868/ https://www.ncbi.nlm.nih.gov/pubmed/25903455 http://dx.doi.org/10.1186/s13052-015-0133-7 |
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author | Diaz, Jahaziel Morales-Romero, Jaime Pérez-Gil, Gustavo Bedolla-Barajas, Martín Delgado-Figueroa, Netzahualpilli García-Román, Rebeca López-López, Omar Bañuelos, Evelyn Rizada-Antel, Cristal Zenteno-Cuevas, Roberto Ramos-Ligonio, Ángel Sampieri, Clara Luz Orozco-Alatorre, Luis Gustavo Mora, Silvia I Montero, Hilda |
author_facet | Diaz, Jahaziel Morales-Romero, Jaime Pérez-Gil, Gustavo Bedolla-Barajas, Martín Delgado-Figueroa, Netzahualpilli García-Román, Rebeca López-López, Omar Bañuelos, Evelyn Rizada-Antel, Cristal Zenteno-Cuevas, Roberto Ramos-Ligonio, Ángel Sampieri, Clara Luz Orozco-Alatorre, Luis Gustavo Mora, Silvia I Montero, Hilda |
author_sort | Diaz, Jahaziel |
collection | PubMed |
description | BACKGROUND: Acute respiratory infections (ARIs) cause illness. Children under five years of age are highly vulnerable to these infections. Viral coinfection or multiple viral infection is a variable that can have a significant impact on the evolution of these diseases. METHODS: This cross-sectional study was carried out in Mexican children (under five years of age) who had an ARI and who were treated by an emergency service in a hospital in Guadalajara, Jalisco, Mexico. The viral etiology, as well as the presence of multiple viral infections, was determined. A structured questionnaire was used to obtain demographic and clinical information. Odds ratio (OR) was calculated, and univariate and multivariate analyses using logistic regression were performed. RESULTS: In the study population, metapneumovirus (hMPV) was the most frequent virus (22%), followed by adenovirus (hAD) (16%), respiratory syncytial virus (RSV) (14%), rhinovirus (hRV) (12%), bocavirus (hBoV) (9%), influenza virus (IF) (7%), and parainfluenza (PIF) (4%). The frequency of viral coinfections was 31.62%, and multiple logistic regression analysis revealed that hMPV, RSV, PIF, and hBoV were independently associated with multiple viral infection. No difference was found in the clinical manifestation of children with simple and multiple infections. Simple hMPV infection was associated with patients who presented with severe ARI. Using a multivariate analysis, we found that overcrowding is associated with coinfection when the viral etiology was hRV (OR = 2.56, 95% confidence interval (CI) 1.07 to 6.13), IF (OR = 2.56, 95% CI 1.07 to 6.13), PIF (OR = 2.96, 95% CI 1.15 to 7.65), hAD (OR = 2.56, 95% CI 1.07 to 6.13), and hBoV (OR = 2.9, 95% CI 1.14 to 7.34). CONCLUSIONS: Viral coinfections are frequent in children requiring treatment by an emergency service. However, the severity of ARI is similar to that of children with a simple infection. The hMPV is common and may confer a significant disease burden in the Mexican population. Finally, overcrowding is a housing characteristic that favors the development of coinfections. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13052-015-0133-7) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4405868 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-44058682015-04-23 Viral coinfection in acute respiratory infection in Mexican children treated by the emergency service: A cross-sectional study Diaz, Jahaziel Morales-Romero, Jaime Pérez-Gil, Gustavo Bedolla-Barajas, Martín Delgado-Figueroa, Netzahualpilli García-Román, Rebeca López-López, Omar Bañuelos, Evelyn Rizada-Antel, Cristal Zenteno-Cuevas, Roberto Ramos-Ligonio, Ángel Sampieri, Clara Luz Orozco-Alatorre, Luis Gustavo Mora, Silvia I Montero, Hilda Ital J Pediatr Research BACKGROUND: Acute respiratory infections (ARIs) cause illness. Children under five years of age are highly vulnerable to these infections. Viral coinfection or multiple viral infection is a variable that can have a significant impact on the evolution of these diseases. METHODS: This cross-sectional study was carried out in Mexican children (under five years of age) who had an ARI and who were treated by an emergency service in a hospital in Guadalajara, Jalisco, Mexico. The viral etiology, as well as the presence of multiple viral infections, was determined. A structured questionnaire was used to obtain demographic and clinical information. Odds ratio (OR) was calculated, and univariate and multivariate analyses using logistic regression were performed. RESULTS: In the study population, metapneumovirus (hMPV) was the most frequent virus (22%), followed by adenovirus (hAD) (16%), respiratory syncytial virus (RSV) (14%), rhinovirus (hRV) (12%), bocavirus (hBoV) (9%), influenza virus (IF) (7%), and parainfluenza (PIF) (4%). The frequency of viral coinfections was 31.62%, and multiple logistic regression analysis revealed that hMPV, RSV, PIF, and hBoV were independently associated with multiple viral infection. No difference was found in the clinical manifestation of children with simple and multiple infections. Simple hMPV infection was associated with patients who presented with severe ARI. Using a multivariate analysis, we found that overcrowding is associated with coinfection when the viral etiology was hRV (OR = 2.56, 95% confidence interval (CI) 1.07 to 6.13), IF (OR = 2.56, 95% CI 1.07 to 6.13), PIF (OR = 2.96, 95% CI 1.15 to 7.65), hAD (OR = 2.56, 95% CI 1.07 to 6.13), and hBoV (OR = 2.9, 95% CI 1.14 to 7.34). CONCLUSIONS: Viral coinfections are frequent in children requiring treatment by an emergency service. However, the severity of ARI is similar to that of children with a simple infection. The hMPV is common and may confer a significant disease burden in the Mexican population. Finally, overcrowding is a housing characteristic that favors the development of coinfections. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13052-015-0133-7) contains supplementary material, which is available to authorized users. BioMed Central 2015-04-18 /pmc/articles/PMC4405868/ /pubmed/25903455 http://dx.doi.org/10.1186/s13052-015-0133-7 Text en © Diaz et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Diaz, Jahaziel Morales-Romero, Jaime Pérez-Gil, Gustavo Bedolla-Barajas, Martín Delgado-Figueroa, Netzahualpilli García-Román, Rebeca López-López, Omar Bañuelos, Evelyn Rizada-Antel, Cristal Zenteno-Cuevas, Roberto Ramos-Ligonio, Ángel Sampieri, Clara Luz Orozco-Alatorre, Luis Gustavo Mora, Silvia I Montero, Hilda Viral coinfection in acute respiratory infection in Mexican children treated by the emergency service: A cross-sectional study |
title | Viral coinfection in acute respiratory infection in Mexican children treated by the emergency service: A cross-sectional study |
title_full | Viral coinfection in acute respiratory infection in Mexican children treated by the emergency service: A cross-sectional study |
title_fullStr | Viral coinfection in acute respiratory infection in Mexican children treated by the emergency service: A cross-sectional study |
title_full_unstemmed | Viral coinfection in acute respiratory infection in Mexican children treated by the emergency service: A cross-sectional study |
title_short | Viral coinfection in acute respiratory infection in Mexican children treated by the emergency service: A cross-sectional study |
title_sort | viral coinfection in acute respiratory infection in mexican children treated by the emergency service: a cross-sectional study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405868/ https://www.ncbi.nlm.nih.gov/pubmed/25903455 http://dx.doi.org/10.1186/s13052-015-0133-7 |
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