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Primary antiphospholipid syndrome presenting as antiphospholipid syndrome nephropathy: a case report

INTRODUCTION: Primary antiphospholipid syndrome can be a difficult diagnosis in the absence of typical clinical features. We describe an unusual presentation of primary antiphospholipid syndrome mimicking vasculitis for which the only diagnostic clue on initial presentation was antiphospholipid synd...

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Autores principales: Abeysekera, Rajitha Asanga, Wazil, Abdul Wahid Mohomad, Nanayakkara, Nishantha, Ratnatunga, Neelakanthi VI, Fernando, Kaushal Maithree, Thinnarachchi, Jalitha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406029/
https://www.ncbi.nlm.nih.gov/pubmed/25630456
http://dx.doi.org/10.1186/1752-1947-9-28
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author Abeysekera, Rajitha Asanga
Wazil, Abdul Wahid Mohomad
Nanayakkara, Nishantha
Ratnatunga, Neelakanthi VI
Fernando, Kaushal Maithree
Thinnarachchi, Jalitha
author_facet Abeysekera, Rajitha Asanga
Wazil, Abdul Wahid Mohomad
Nanayakkara, Nishantha
Ratnatunga, Neelakanthi VI
Fernando, Kaushal Maithree
Thinnarachchi, Jalitha
author_sort Abeysekera, Rajitha Asanga
collection PubMed
description INTRODUCTION: Primary antiphospholipid syndrome can be a difficult diagnosis in the absence of typical clinical features. We describe an unusual presentation of primary antiphospholipid syndrome mimicking vasculitis for which the only diagnostic clue on initial presentation was antiphospholipid syndrome nephropathy. CASE PRESENTATION: A 29-year-old Sri Lankan woman presented with features mimicking vasculitis with no obvious clinical features of antiphospholipid syndrome. Classical symptoms of antiphospholipid syndrome only appeared months later. A retrospective analysis showed that the only evidence of antiphospholipid syndrome at her first presentation was antiphospholipid syndrome nephropathy on her renal biopsy. CONCLUSIONS: A high degree of suspicion of antiphospholipid syndrome is needed when patients present with non-specific vasculitis features. It has a broad clinical impact as antiphospholipid syndrome can present to any clinician with rare manifestations such as nephropathy. This significantly adds to the advancement of knowledge as antiphospholipid syndrome nephropathy should be recognized as a true entity and considered as a classification criteria for antiphospholipid syndrome.
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spelling pubmed-44060292015-04-23 Primary antiphospholipid syndrome presenting as antiphospholipid syndrome nephropathy: a case report Abeysekera, Rajitha Asanga Wazil, Abdul Wahid Mohomad Nanayakkara, Nishantha Ratnatunga, Neelakanthi VI Fernando, Kaushal Maithree Thinnarachchi, Jalitha J Med Case Rep Case Report INTRODUCTION: Primary antiphospholipid syndrome can be a difficult diagnosis in the absence of typical clinical features. We describe an unusual presentation of primary antiphospholipid syndrome mimicking vasculitis for which the only diagnostic clue on initial presentation was antiphospholipid syndrome nephropathy. CASE PRESENTATION: A 29-year-old Sri Lankan woman presented with features mimicking vasculitis with no obvious clinical features of antiphospholipid syndrome. Classical symptoms of antiphospholipid syndrome only appeared months later. A retrospective analysis showed that the only evidence of antiphospholipid syndrome at her first presentation was antiphospholipid syndrome nephropathy on her renal biopsy. CONCLUSIONS: A high degree of suspicion of antiphospholipid syndrome is needed when patients present with non-specific vasculitis features. It has a broad clinical impact as antiphospholipid syndrome can present to any clinician with rare manifestations such as nephropathy. This significantly adds to the advancement of knowledge as antiphospholipid syndrome nephropathy should be recognized as a true entity and considered as a classification criteria for antiphospholipid syndrome. BioMed Central 2015-01-29 /pmc/articles/PMC4406029/ /pubmed/25630456 http://dx.doi.org/10.1186/1752-1947-9-28 Text en © Abeysekera et al.; licensee BioMed Central. 2015 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Abeysekera, Rajitha Asanga
Wazil, Abdul Wahid Mohomad
Nanayakkara, Nishantha
Ratnatunga, Neelakanthi VI
Fernando, Kaushal Maithree
Thinnarachchi, Jalitha
Primary antiphospholipid syndrome presenting as antiphospholipid syndrome nephropathy: a case report
title Primary antiphospholipid syndrome presenting as antiphospholipid syndrome nephropathy: a case report
title_full Primary antiphospholipid syndrome presenting as antiphospholipid syndrome nephropathy: a case report
title_fullStr Primary antiphospholipid syndrome presenting as antiphospholipid syndrome nephropathy: a case report
title_full_unstemmed Primary antiphospholipid syndrome presenting as antiphospholipid syndrome nephropathy: a case report
title_short Primary antiphospholipid syndrome presenting as antiphospholipid syndrome nephropathy: a case report
title_sort primary antiphospholipid syndrome presenting as antiphospholipid syndrome nephropathy: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406029/
https://www.ncbi.nlm.nih.gov/pubmed/25630456
http://dx.doi.org/10.1186/1752-1947-9-28
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