STIM1L traps and gates Orai1 channels without remodeling the cortical ER

STIM proteins populate and expand cortical endoplasmic reticulum (ER) sheets to mediate store-operated Ca(2+) entry (SOCE) by trapping and gating Orai channels in ER-plasma membrane clusters. A longer splice variant, STIM1L, forms permanent ER-plasma membrane clusters and mediates rapid Ca(2+) influ...

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Detalles Bibliográficos
Autores principales: Saüc, Sophie, Bulla, Monica, Nunes, Paula, Orci, Lelio, Marchetti, Anna, Antigny, Fabrice, Bernheim, Laurent, Cosson, Pierre, Frieden, Maud, Demaurex, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406124/
https://www.ncbi.nlm.nih.gov/pubmed/25736291
http://dx.doi.org/10.1242/jcs.164228

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