The impact of FGFR1 and FRS2α expression on sorafenib treatment in metastatic renal cell carcinoma

BACKGROUND: Angiogenesis plays a role in tumor growth and is partly mediated by factors in both the fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF) pathways. Durable clinical responses with VEGF tyrosine kinase inhibitors (TKIs) may be limited by intrinsic tumor resistan...

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Detalles Bibliográficos
Autores principales: Ho, Thai H, Liu, Xian-De, Huang, Yanqing, Warneke, Carla L, Johnson, Marcella M, Hoang, Anh, Tamboli, Pheroze, Wang, Fen, Jonasch, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406182/
https://www.ncbi.nlm.nih.gov/pubmed/25900027
http://dx.doi.org/10.1186/s12885-015-1302-1

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