Cargando…

Some inferences from in vivo experiments with metal and metal oxide nanoparticles: the pulmonary phagocytosis response, subchronic systemic toxicity and genotoxicity, regulatory proposals, searching for bioprotectors (a self-overview)

The purpose of this paper is to overview and summarize previously published results of our experiments on white rats exposed to either a single intratracheal instillation or repeated intraperitoneal injections of silver, gold, iron oxide, copper oxide, nickel oxide, and manganese oxide nanoparticles...

Descripción completa

Detalles Bibliográficos
Autores principales: Katsnelson, Boris A, Privalova, Larisa I, Sutunkova, Marina P, Gurvich, Vladimir B, Loginova, Nadezhda V, Minigalieva, Ilzira A, Kireyeva, Ekaterina P, Shur, Vladimir Y, Shishkina, Ekaterina V, Beikin, Ya B, Makeyev, Oleg H, Valamina, Irene E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406262/
https://www.ncbi.nlm.nih.gov/pubmed/25945048
http://dx.doi.org/10.2147/IJN.S80843
_version_ 1782367748251189248
author Katsnelson, Boris A
Privalova, Larisa I
Sutunkova, Marina P
Gurvich, Vladimir B
Loginova, Nadezhda V
Minigalieva, Ilzira A
Kireyeva, Ekaterina P
Shur, Vladimir Y
Shishkina, Ekaterina V
Beikin, Ya B
Makeyev, Oleg H
Valamina, Irene E
author_facet Katsnelson, Boris A
Privalova, Larisa I
Sutunkova, Marina P
Gurvich, Vladimir B
Loginova, Nadezhda V
Minigalieva, Ilzira A
Kireyeva, Ekaterina P
Shur, Vladimir Y
Shishkina, Ekaterina V
Beikin, Ya B
Makeyev, Oleg H
Valamina, Irene E
author_sort Katsnelson, Boris A
collection PubMed
description The purpose of this paper is to overview and summarize previously published results of our experiments on white rats exposed to either a single intratracheal instillation or repeated intraperitoneal injections of silver, gold, iron oxide, copper oxide, nickel oxide, and manganese oxide nanoparticles (NPs) in stable water suspensions without any chemical additives. Based on these results and some corroborating data of other researchers we maintain that these NPs are much more noxious on both cellular and systemic levels as compared with their 1 μm or even submicron counterparts. However, within the nanometer range the dependence of systemic toxicity on particle size is intricate and non-unique due to complex and often contra-directional relationships between the intrinsic biological aggressiveness of the specific NPs, on the one hand, and complex mechanisms that control their biokinetics, on the other. Our data testify to the high activity of the pulmonary phagocytosis of NPs deposited in airways. This fact suggests that safe levels of exposure to airborne NPs are possible in principle. However, there are no reliable foundations for establishing different permissible exposure levels for particles of different size within the nanometric range. For workroom air, such permissible exposure levels of metallic NP can be proposed at this stage, even if tentatively, based on a sufficiently conservative approach of decreasing approximately tenfold the exposure limits officially established for respective micro-scale industrial aerosols. It was shown that against the background of adequately composed combinations of some bioactive agents (comprising pectin, multivitamin-multimineral preparations, some amino acids, and omega-3 polyunsaturated fatty acid) the systemic toxicity and even genotoxicity of metallic NPs could be markedly attenuated. Therefore we believe that, along with decreasing NP-exposures, enhancing organisms’ resistance to their adverse action with the help of such bioprotectors can prove an efficient auxiliary tool of health risk management in occupations connected with them.
format Online
Article
Text
id pubmed-4406262
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-44062622015-05-05 Some inferences from in vivo experiments with metal and metal oxide nanoparticles: the pulmonary phagocytosis response, subchronic systemic toxicity and genotoxicity, regulatory proposals, searching for bioprotectors (a self-overview) Katsnelson, Boris A Privalova, Larisa I Sutunkova, Marina P Gurvich, Vladimir B Loginova, Nadezhda V Minigalieva, Ilzira A Kireyeva, Ekaterina P Shur, Vladimir Y Shishkina, Ekaterina V Beikin, Ya B Makeyev, Oleg H Valamina, Irene E Int J Nanomedicine Review The purpose of this paper is to overview and summarize previously published results of our experiments on white rats exposed to either a single intratracheal instillation or repeated intraperitoneal injections of silver, gold, iron oxide, copper oxide, nickel oxide, and manganese oxide nanoparticles (NPs) in stable water suspensions without any chemical additives. Based on these results and some corroborating data of other researchers we maintain that these NPs are much more noxious on both cellular and systemic levels as compared with their 1 μm or even submicron counterparts. However, within the nanometer range the dependence of systemic toxicity on particle size is intricate and non-unique due to complex and often contra-directional relationships between the intrinsic biological aggressiveness of the specific NPs, on the one hand, and complex mechanisms that control their biokinetics, on the other. Our data testify to the high activity of the pulmonary phagocytosis of NPs deposited in airways. This fact suggests that safe levels of exposure to airborne NPs are possible in principle. However, there are no reliable foundations for establishing different permissible exposure levels for particles of different size within the nanometric range. For workroom air, such permissible exposure levels of metallic NP can be proposed at this stage, even if tentatively, based on a sufficiently conservative approach of decreasing approximately tenfold the exposure limits officially established for respective micro-scale industrial aerosols. It was shown that against the background of adequately composed combinations of some bioactive agents (comprising pectin, multivitamin-multimineral preparations, some amino acids, and omega-3 polyunsaturated fatty acid) the systemic toxicity and even genotoxicity of metallic NPs could be markedly attenuated. Therefore we believe that, along with decreasing NP-exposures, enhancing organisms’ resistance to their adverse action with the help of such bioprotectors can prove an efficient auxiliary tool of health risk management in occupations connected with them. Dove Medical Press 2015-04-16 /pmc/articles/PMC4406262/ /pubmed/25945048 http://dx.doi.org/10.2147/IJN.S80843 Text en © 2015 Katsnelson et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Katsnelson, Boris A
Privalova, Larisa I
Sutunkova, Marina P
Gurvich, Vladimir B
Loginova, Nadezhda V
Minigalieva, Ilzira A
Kireyeva, Ekaterina P
Shur, Vladimir Y
Shishkina, Ekaterina V
Beikin, Ya B
Makeyev, Oleg H
Valamina, Irene E
Some inferences from in vivo experiments with metal and metal oxide nanoparticles: the pulmonary phagocytosis response, subchronic systemic toxicity and genotoxicity, regulatory proposals, searching for bioprotectors (a self-overview)
title Some inferences from in vivo experiments with metal and metal oxide nanoparticles: the pulmonary phagocytosis response, subchronic systemic toxicity and genotoxicity, regulatory proposals, searching for bioprotectors (a self-overview)
title_full Some inferences from in vivo experiments with metal and metal oxide nanoparticles: the pulmonary phagocytosis response, subchronic systemic toxicity and genotoxicity, regulatory proposals, searching for bioprotectors (a self-overview)
title_fullStr Some inferences from in vivo experiments with metal and metal oxide nanoparticles: the pulmonary phagocytosis response, subchronic systemic toxicity and genotoxicity, regulatory proposals, searching for bioprotectors (a self-overview)
title_full_unstemmed Some inferences from in vivo experiments with metal and metal oxide nanoparticles: the pulmonary phagocytosis response, subchronic systemic toxicity and genotoxicity, regulatory proposals, searching for bioprotectors (a self-overview)
title_short Some inferences from in vivo experiments with metal and metal oxide nanoparticles: the pulmonary phagocytosis response, subchronic systemic toxicity and genotoxicity, regulatory proposals, searching for bioprotectors (a self-overview)
title_sort some inferences from in vivo experiments with metal and metal oxide nanoparticles: the pulmonary phagocytosis response, subchronic systemic toxicity and genotoxicity, regulatory proposals, searching for bioprotectors (a self-overview)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406262/
https://www.ncbi.nlm.nih.gov/pubmed/25945048
http://dx.doi.org/10.2147/IJN.S80843
work_keys_str_mv AT katsnelsonborisa someinferencesfrominvivoexperimentswithmetalandmetaloxidenanoparticlesthepulmonaryphagocytosisresponsesubchronicsystemictoxicityandgenotoxicityregulatoryproposalssearchingforbioprotectorsaselfoverview
AT privalovalarisai someinferencesfrominvivoexperimentswithmetalandmetaloxidenanoparticlesthepulmonaryphagocytosisresponsesubchronicsystemictoxicityandgenotoxicityregulatoryproposalssearchingforbioprotectorsaselfoverview
AT sutunkovamarinap someinferencesfrominvivoexperimentswithmetalandmetaloxidenanoparticlesthepulmonaryphagocytosisresponsesubchronicsystemictoxicityandgenotoxicityregulatoryproposalssearchingforbioprotectorsaselfoverview
AT gurvichvladimirb someinferencesfrominvivoexperimentswithmetalandmetaloxidenanoparticlesthepulmonaryphagocytosisresponsesubchronicsystemictoxicityandgenotoxicityregulatoryproposalssearchingforbioprotectorsaselfoverview
AT loginovanadezhdav someinferencesfrominvivoexperimentswithmetalandmetaloxidenanoparticlesthepulmonaryphagocytosisresponsesubchronicsystemictoxicityandgenotoxicityregulatoryproposalssearchingforbioprotectorsaselfoverview
AT minigalievailziraa someinferencesfrominvivoexperimentswithmetalandmetaloxidenanoparticlesthepulmonaryphagocytosisresponsesubchronicsystemictoxicityandgenotoxicityregulatoryproposalssearchingforbioprotectorsaselfoverview
AT kireyevaekaterinap someinferencesfrominvivoexperimentswithmetalandmetaloxidenanoparticlesthepulmonaryphagocytosisresponsesubchronicsystemictoxicityandgenotoxicityregulatoryproposalssearchingforbioprotectorsaselfoverview
AT shurvladimiry someinferencesfrominvivoexperimentswithmetalandmetaloxidenanoparticlesthepulmonaryphagocytosisresponsesubchronicsystemictoxicityandgenotoxicityregulatoryproposalssearchingforbioprotectorsaselfoverview
AT shishkinaekaterinav someinferencesfrominvivoexperimentswithmetalandmetaloxidenanoparticlesthepulmonaryphagocytosisresponsesubchronicsystemictoxicityandgenotoxicityregulatoryproposalssearchingforbioprotectorsaselfoverview
AT beikinyab someinferencesfrominvivoexperimentswithmetalandmetaloxidenanoparticlesthepulmonaryphagocytosisresponsesubchronicsystemictoxicityandgenotoxicityregulatoryproposalssearchingforbioprotectorsaselfoverview
AT makeyevolegh someinferencesfrominvivoexperimentswithmetalandmetaloxidenanoparticlesthepulmonaryphagocytosisresponsesubchronicsystemictoxicityandgenotoxicityregulatoryproposalssearchingforbioprotectorsaselfoverview
AT valaminairenee someinferencesfrominvivoexperimentswithmetalandmetaloxidenanoparticlesthepulmonaryphagocytosisresponsesubchronicsystemictoxicityandgenotoxicityregulatoryproposalssearchingforbioprotectorsaselfoverview