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Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2
We recently identified a novel susceptibility variant, rs865686, for estrogen-receptor positive breast cancer at 9q31.2. Here, we report a fine-mapping analysis of the 9q31.2 susceptibility locus using 43 160 cases and 42 600 controls of European ancestry ascertained from 52 studies and a further 57...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406292/ https://www.ncbi.nlm.nih.gov/pubmed/25652398 http://dx.doi.org/10.1093/hmg/ddv035 |
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author | Orr, Nick Dudbridge, Frank Dryden, Nicola Maguire, Sarah Novo, Daniela Perrakis, Eleni Johnson, Nichola Ghoussaini, Maya Hopper, John L. Southey, Melissa C. Apicella, Carmel Stone, Jennifer Schmidt, Marjanka K. Broeks, Annegien Van't Veer, Laura J. Hogervorst, Frans B. Fasching, Peter A. Haeberle, Lothar Ekici, Arif B. Beckmann, Matthias W. Gibson, Lorna Aitken, Zoe Warren, Helen Sawyer, Elinor Tomlinson, Ian Kerin, Michael J. Miller, Nicola Burwinkel, Barbara Marme, Frederik Schneeweiss, Andreas Sohn, Chistof Guénel, Pascal Truong, Thérèse Cordina-Duverger, Emilie Sanchez, Marie Bojesen, Stig E. Nordestgaard, Børge G. Nielsen, Sune F. Flyger, Henrik Benitez, Javier Zamora, Maria Pilar Arias Perez, Jose Ignacio Menéndez, Primitiva Anton-Culver, Hoda Neuhausen, Susan L. Brenner, Hermann Dieffenbach, Aida Karina Arndt, Volker Stegmaier, Christa Hamann, Ute Brauch, Hiltrud Justenhoven, Christina Brüning, Thomas Ko, Yon-Dschun Nevanlinna, Heli Aittomäki, Kristiina Blomqvist, Carl Khan, Sofia Bogdanova, Natalia Dörk, Thilo Lindblom, Annika Margolin, Sara Mannermaa, Arto Kataja, Vesa Kosma, Veli-Matti Hartikainen, Jaana M. Chenevix-Trench, Georgia Beesley, Jonathan Lambrechts, Diether Moisse, Matthieu Floris, Guiseppe Beuselinck, Benoit Chang-Claude, Jenny Rudolph, Anja Seibold, Petra Flesch-Janys, Dieter Radice, Paolo Peterlongo, Paolo Peissel, Bernard Pensotti, Valeria Couch, Fergus J. Olson, Janet E. Slettedahl, Seth Vachon, Celine Giles, Graham G. Milne, Roger L. McLean, Catriona Haiman, Christopher A. Henderson, Brian E. Schumacher, Fredrick Le Marchand, Loic Simard, Jacques Goldberg, Mark S. Labrèche, France Dumont, Martine Kristensen, Vessela Alnæs, Grethe Grenaker Nord, Silje Borresen-Dale, Anne-Lise Zheng, Wei Deming-Halverson, Sandra Shrubsole, Martha Long, Jirong Winqvist, Robert Pylkäs, Katri Jukkola-Vuorinen, Arja Grip, Mervi Andrulis, Irene L. Knight, Julia A. Glendon, Gord Tchatchou, Sandrine Devilee, Peter Tollenaar, Robertus A. E. M. Seynaeve, Caroline M. Van Asperen, Christi J. Garcia-Closas, Montserrat Figueroa, Jonine Chanock, Stephen J. Lissowska, Jolanta Czene, Kamila Darabi, Hatef Eriksson, Mikael Klevebring, Daniel Hooning, Maartje J. Hollestelle, Antoinette van Deurzen, Carolien H. M. Kriege, Mieke Hall, Per Li, Jingmei Liu, Jianjun Humphreys, Keith Cox, Angela Cross, Simon S. Reed, Malcolm W. R. Pharoah, Paul D. P. Dunning, Alison M. Shah, Mitul Perkins, Barbara J. Jakubowska, Anna Lubinski, Jan Jaworska-Bieniek, Katarzyna Durda, Katarzyna Ashworth, Alan Swerdlow, Anthony Jones, Michael Schoemaker, Minouk J. Meindl, Alfons Schmutzler, Rita K. Olswold, Curtis Slager, Susan Toland, Amanda E. Yannoukakos, Drakoulis Muir, Kenneth Lophatananon, Artitaya Stewart-Brown, Sarah Siriwanarangsan, Pornthep Matsuo, Keitaro Ito, Hidema Iwata, Hiroji Ishiguro, Junko Wu, Anna H. Tseng, Chiu-chen Van Den Berg, David Stram, Daniel O. Teo, Soo Hwang Yip, Cheng Har Kang, Peter Ikram, Mohammad Kamran Shu, Xiao-Ou Lu, Wei Gao, Yu-Tang Cai, Hui Kang, Daehee Choi, Ji-Yeob Park, Sue K. Noh, Dong-Young Hartman, Mikael Miao, Hui Lim, Wei Yen Lee, Soo Chin Sangrajrang, Suleeporn Gaborieau, Valerie Brennan, Paul Mckay, James Wu, Pei-Ei Hou, Ming-Feng Yu, Jyh-Cherng Shen, Chen-Yang Blot, William Cai, Qiuyin Signorello, Lisa B. Luccarini, Craig Bayes, Caroline Ahmed, Shahana Maranian, Mel Healey, Catherine S. González-Neira, Anna Pita, Guillermo Alonso, M. Rosario Álvarez, Nuria Herrero, Daniel Tessier, Daniel C. Vincent, Daniel Bacot, Francois Hunter, David J. Lindstrom, Sara Dennis, Joe Michailidou, Kyriaki Bolla, Manjeet K. Easton, Douglas F. dos Santos Silva, Isabel Fletcher, Olivia Peto, Julian |
author_facet | Orr, Nick Dudbridge, Frank Dryden, Nicola Maguire, Sarah Novo, Daniela Perrakis, Eleni Johnson, Nichola Ghoussaini, Maya Hopper, John L. Southey, Melissa C. Apicella, Carmel Stone, Jennifer Schmidt, Marjanka K. Broeks, Annegien Van't Veer, Laura J. Hogervorst, Frans B. Fasching, Peter A. Haeberle, Lothar Ekici, Arif B. Beckmann, Matthias W. Gibson, Lorna Aitken, Zoe Warren, Helen Sawyer, Elinor Tomlinson, Ian Kerin, Michael J. Miller, Nicola Burwinkel, Barbara Marme, Frederik Schneeweiss, Andreas Sohn, Chistof Guénel, Pascal Truong, Thérèse Cordina-Duverger, Emilie Sanchez, Marie Bojesen, Stig E. Nordestgaard, Børge G. Nielsen, Sune F. Flyger, Henrik Benitez, Javier Zamora, Maria Pilar Arias Perez, Jose Ignacio Menéndez, Primitiva Anton-Culver, Hoda Neuhausen, Susan L. Brenner, Hermann Dieffenbach, Aida Karina Arndt, Volker Stegmaier, Christa Hamann, Ute Brauch, Hiltrud Justenhoven, Christina Brüning, Thomas Ko, Yon-Dschun Nevanlinna, Heli Aittomäki, Kristiina Blomqvist, Carl Khan, Sofia Bogdanova, Natalia Dörk, Thilo Lindblom, Annika Margolin, Sara Mannermaa, Arto Kataja, Vesa Kosma, Veli-Matti Hartikainen, Jaana M. Chenevix-Trench, Georgia Beesley, Jonathan Lambrechts, Diether Moisse, Matthieu Floris, Guiseppe Beuselinck, Benoit Chang-Claude, Jenny Rudolph, Anja Seibold, Petra Flesch-Janys, Dieter Radice, Paolo Peterlongo, Paolo Peissel, Bernard Pensotti, Valeria Couch, Fergus J. Olson, Janet E. Slettedahl, Seth Vachon, Celine Giles, Graham G. Milne, Roger L. McLean, Catriona Haiman, Christopher A. Henderson, Brian E. Schumacher, Fredrick Le Marchand, Loic Simard, Jacques Goldberg, Mark S. Labrèche, France Dumont, Martine Kristensen, Vessela Alnæs, Grethe Grenaker Nord, Silje Borresen-Dale, Anne-Lise Zheng, Wei Deming-Halverson, Sandra Shrubsole, Martha Long, Jirong Winqvist, Robert Pylkäs, Katri Jukkola-Vuorinen, Arja Grip, Mervi Andrulis, Irene L. Knight, Julia A. Glendon, Gord Tchatchou, Sandrine Devilee, Peter Tollenaar, Robertus A. E. M. Seynaeve, Caroline M. Van Asperen, Christi J. Garcia-Closas, Montserrat Figueroa, Jonine Chanock, Stephen J. Lissowska, Jolanta Czene, Kamila Darabi, Hatef Eriksson, Mikael Klevebring, Daniel Hooning, Maartje J. Hollestelle, Antoinette van Deurzen, Carolien H. M. Kriege, Mieke Hall, Per Li, Jingmei Liu, Jianjun Humphreys, Keith Cox, Angela Cross, Simon S. Reed, Malcolm W. R. Pharoah, Paul D. P. Dunning, Alison M. Shah, Mitul Perkins, Barbara J. Jakubowska, Anna Lubinski, Jan Jaworska-Bieniek, Katarzyna Durda, Katarzyna Ashworth, Alan Swerdlow, Anthony Jones, Michael Schoemaker, Minouk J. Meindl, Alfons Schmutzler, Rita K. Olswold, Curtis Slager, Susan Toland, Amanda E. Yannoukakos, Drakoulis Muir, Kenneth Lophatananon, Artitaya Stewart-Brown, Sarah Siriwanarangsan, Pornthep Matsuo, Keitaro Ito, Hidema Iwata, Hiroji Ishiguro, Junko Wu, Anna H. Tseng, Chiu-chen Van Den Berg, David Stram, Daniel O. Teo, Soo Hwang Yip, Cheng Har Kang, Peter Ikram, Mohammad Kamran Shu, Xiao-Ou Lu, Wei Gao, Yu-Tang Cai, Hui Kang, Daehee Choi, Ji-Yeob Park, Sue K. Noh, Dong-Young Hartman, Mikael Miao, Hui Lim, Wei Yen Lee, Soo Chin Sangrajrang, Suleeporn Gaborieau, Valerie Brennan, Paul Mckay, James Wu, Pei-Ei Hou, Ming-Feng Yu, Jyh-Cherng Shen, Chen-Yang Blot, William Cai, Qiuyin Signorello, Lisa B. Luccarini, Craig Bayes, Caroline Ahmed, Shahana Maranian, Mel Healey, Catherine S. González-Neira, Anna Pita, Guillermo Alonso, M. Rosario Álvarez, Nuria Herrero, Daniel Tessier, Daniel C. Vincent, Daniel Bacot, Francois Hunter, David J. Lindstrom, Sara Dennis, Joe Michailidou, Kyriaki Bolla, Manjeet K. Easton, Douglas F. dos Santos Silva, Isabel Fletcher, Olivia Peto, Julian |
author_sort | Orr, Nick |
collection | PubMed |
description | We recently identified a novel susceptibility variant, rs865686, for estrogen-receptor positive breast cancer at 9q31.2. Here, we report a fine-mapping analysis of the 9q31.2 susceptibility locus using 43 160 cases and 42 600 controls of European ancestry ascertained from 52 studies and a further 5795 cases and 6624 controls of Asian ancestry from nine studies. Single nucleotide polymorphism (SNP) rs676256 was most strongly associated with risk in Europeans (odds ratios [OR] = 0.90 [0.88–0.92]; P-value = 1.58 × 10(−25)). This SNP is one of a cluster of highly correlated variants, including rs865686, that spans ∼14.5 kb. We identified two additional independent association signals demarcated by SNPs rs10816625 (OR = 1.12 [1.08–1.17]; P-value = 7.89 × 10(−09)) and rs13294895 (OR = 1.09 [1.06–1.12]; P-value = 2.97 × 10(−11)). SNP rs10816625, but not rs13294895, was also associated with risk of breast cancer in Asian individuals (OR = 1.12 [1.06–1.18]; P-value = 2.77 × 10(−05)). Functional genomic annotation using data derived from breast cancer cell-line models indicates that these SNPs localise to putative enhancer elements that bind known drivers of hormone-dependent breast cancer, including ER-α, FOXA1 and GATA-3. In vitro analyses indicate that rs10816625 and rs13294895 have allele-specific effects on enhancer activity and suggest chromatin interactions with the KLF4 gene locus. These results demonstrate the power of dense genotyping in large studies to identify independent susceptibility variants. Analysis of associations using subjects with different ancestry, combined with bioinformatic and genomic characterisation, can provide strong evidence for the likely causative alleles and their functional basis. |
format | Online Article Text |
id | pubmed-4406292 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-44062922015-04-27 Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2 Orr, Nick Dudbridge, Frank Dryden, Nicola Maguire, Sarah Novo, Daniela Perrakis, Eleni Johnson, Nichola Ghoussaini, Maya Hopper, John L. Southey, Melissa C. Apicella, Carmel Stone, Jennifer Schmidt, Marjanka K. Broeks, Annegien Van't Veer, Laura J. Hogervorst, Frans B. Fasching, Peter A. Haeberle, Lothar Ekici, Arif B. Beckmann, Matthias W. Gibson, Lorna Aitken, Zoe Warren, Helen Sawyer, Elinor Tomlinson, Ian Kerin, Michael J. Miller, Nicola Burwinkel, Barbara Marme, Frederik Schneeweiss, Andreas Sohn, Chistof Guénel, Pascal Truong, Thérèse Cordina-Duverger, Emilie Sanchez, Marie Bojesen, Stig E. Nordestgaard, Børge G. Nielsen, Sune F. Flyger, Henrik Benitez, Javier Zamora, Maria Pilar Arias Perez, Jose Ignacio Menéndez, Primitiva Anton-Culver, Hoda Neuhausen, Susan L. Brenner, Hermann Dieffenbach, Aida Karina Arndt, Volker Stegmaier, Christa Hamann, Ute Brauch, Hiltrud Justenhoven, Christina Brüning, Thomas Ko, Yon-Dschun Nevanlinna, Heli Aittomäki, Kristiina Blomqvist, Carl Khan, Sofia Bogdanova, Natalia Dörk, Thilo Lindblom, Annika Margolin, Sara Mannermaa, Arto Kataja, Vesa Kosma, Veli-Matti Hartikainen, Jaana M. Chenevix-Trench, Georgia Beesley, Jonathan Lambrechts, Diether Moisse, Matthieu Floris, Guiseppe Beuselinck, Benoit Chang-Claude, Jenny Rudolph, Anja Seibold, Petra Flesch-Janys, Dieter Radice, Paolo Peterlongo, Paolo Peissel, Bernard Pensotti, Valeria Couch, Fergus J. Olson, Janet E. Slettedahl, Seth Vachon, Celine Giles, Graham G. Milne, Roger L. McLean, Catriona Haiman, Christopher A. Henderson, Brian E. Schumacher, Fredrick Le Marchand, Loic Simard, Jacques Goldberg, Mark S. Labrèche, France Dumont, Martine Kristensen, Vessela Alnæs, Grethe Grenaker Nord, Silje Borresen-Dale, Anne-Lise Zheng, Wei Deming-Halverson, Sandra Shrubsole, Martha Long, Jirong Winqvist, Robert Pylkäs, Katri Jukkola-Vuorinen, Arja Grip, Mervi Andrulis, Irene L. Knight, Julia A. Glendon, Gord Tchatchou, Sandrine Devilee, Peter Tollenaar, Robertus A. E. M. Seynaeve, Caroline M. Van Asperen, Christi J. Garcia-Closas, Montserrat Figueroa, Jonine Chanock, Stephen J. Lissowska, Jolanta Czene, Kamila Darabi, Hatef Eriksson, Mikael Klevebring, Daniel Hooning, Maartje J. Hollestelle, Antoinette van Deurzen, Carolien H. M. Kriege, Mieke Hall, Per Li, Jingmei Liu, Jianjun Humphreys, Keith Cox, Angela Cross, Simon S. Reed, Malcolm W. R. Pharoah, Paul D. P. Dunning, Alison M. Shah, Mitul Perkins, Barbara J. Jakubowska, Anna Lubinski, Jan Jaworska-Bieniek, Katarzyna Durda, Katarzyna Ashworth, Alan Swerdlow, Anthony Jones, Michael Schoemaker, Minouk J. Meindl, Alfons Schmutzler, Rita K. Olswold, Curtis Slager, Susan Toland, Amanda E. Yannoukakos, Drakoulis Muir, Kenneth Lophatananon, Artitaya Stewart-Brown, Sarah Siriwanarangsan, Pornthep Matsuo, Keitaro Ito, Hidema Iwata, Hiroji Ishiguro, Junko Wu, Anna H. Tseng, Chiu-chen Van Den Berg, David Stram, Daniel O. Teo, Soo Hwang Yip, Cheng Har Kang, Peter Ikram, Mohammad Kamran Shu, Xiao-Ou Lu, Wei Gao, Yu-Tang Cai, Hui Kang, Daehee Choi, Ji-Yeob Park, Sue K. Noh, Dong-Young Hartman, Mikael Miao, Hui Lim, Wei Yen Lee, Soo Chin Sangrajrang, Suleeporn Gaborieau, Valerie Brennan, Paul Mckay, James Wu, Pei-Ei Hou, Ming-Feng Yu, Jyh-Cherng Shen, Chen-Yang Blot, William Cai, Qiuyin Signorello, Lisa B. Luccarini, Craig Bayes, Caroline Ahmed, Shahana Maranian, Mel Healey, Catherine S. González-Neira, Anna Pita, Guillermo Alonso, M. Rosario Álvarez, Nuria Herrero, Daniel Tessier, Daniel C. Vincent, Daniel Bacot, Francois Hunter, David J. Lindstrom, Sara Dennis, Joe Michailidou, Kyriaki Bolla, Manjeet K. Easton, Douglas F. dos Santos Silva, Isabel Fletcher, Olivia Peto, Julian Hum Mol Genet Association Studies Articles We recently identified a novel susceptibility variant, rs865686, for estrogen-receptor positive breast cancer at 9q31.2. Here, we report a fine-mapping analysis of the 9q31.2 susceptibility locus using 43 160 cases and 42 600 controls of European ancestry ascertained from 52 studies and a further 5795 cases and 6624 controls of Asian ancestry from nine studies. Single nucleotide polymorphism (SNP) rs676256 was most strongly associated with risk in Europeans (odds ratios [OR] = 0.90 [0.88–0.92]; P-value = 1.58 × 10(−25)). This SNP is one of a cluster of highly correlated variants, including rs865686, that spans ∼14.5 kb. We identified two additional independent association signals demarcated by SNPs rs10816625 (OR = 1.12 [1.08–1.17]; P-value = 7.89 × 10(−09)) and rs13294895 (OR = 1.09 [1.06–1.12]; P-value = 2.97 × 10(−11)). SNP rs10816625, but not rs13294895, was also associated with risk of breast cancer in Asian individuals (OR = 1.12 [1.06–1.18]; P-value = 2.77 × 10(−05)). Functional genomic annotation using data derived from breast cancer cell-line models indicates that these SNPs localise to putative enhancer elements that bind known drivers of hormone-dependent breast cancer, including ER-α, FOXA1 and GATA-3. In vitro analyses indicate that rs10816625 and rs13294895 have allele-specific effects on enhancer activity and suggest chromatin interactions with the KLF4 gene locus. These results demonstrate the power of dense genotyping in large studies to identify independent susceptibility variants. Analysis of associations using subjects with different ancestry, combined with bioinformatic and genomic characterisation, can provide strong evidence for the likely causative alleles and their functional basis. Oxford University Press 2015-05-15 2015-02-04 /pmc/articles/PMC4406292/ /pubmed/25652398 http://dx.doi.org/10.1093/hmg/ddv035 Text en © The Author 2015. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Association Studies Articles Orr, Nick Dudbridge, Frank Dryden, Nicola Maguire, Sarah Novo, Daniela Perrakis, Eleni Johnson, Nichola Ghoussaini, Maya Hopper, John L. Southey, Melissa C. Apicella, Carmel Stone, Jennifer Schmidt, Marjanka K. Broeks, Annegien Van't Veer, Laura J. Hogervorst, Frans B. Fasching, Peter A. Haeberle, Lothar Ekici, Arif B. Beckmann, Matthias W. Gibson, Lorna Aitken, Zoe Warren, Helen Sawyer, Elinor Tomlinson, Ian Kerin, Michael J. Miller, Nicola Burwinkel, Barbara Marme, Frederik Schneeweiss, Andreas Sohn, Chistof Guénel, Pascal Truong, Thérèse Cordina-Duverger, Emilie Sanchez, Marie Bojesen, Stig E. Nordestgaard, Børge G. Nielsen, Sune F. Flyger, Henrik Benitez, Javier Zamora, Maria Pilar Arias Perez, Jose Ignacio Menéndez, Primitiva Anton-Culver, Hoda Neuhausen, Susan L. Brenner, Hermann Dieffenbach, Aida Karina Arndt, Volker Stegmaier, Christa Hamann, Ute Brauch, Hiltrud Justenhoven, Christina Brüning, Thomas Ko, Yon-Dschun Nevanlinna, Heli Aittomäki, Kristiina Blomqvist, Carl Khan, Sofia Bogdanova, Natalia Dörk, Thilo Lindblom, Annika Margolin, Sara Mannermaa, Arto Kataja, Vesa Kosma, Veli-Matti Hartikainen, Jaana M. Chenevix-Trench, Georgia Beesley, Jonathan Lambrechts, Diether Moisse, Matthieu Floris, Guiseppe Beuselinck, Benoit Chang-Claude, Jenny Rudolph, Anja Seibold, Petra Flesch-Janys, Dieter Radice, Paolo Peterlongo, Paolo Peissel, Bernard Pensotti, Valeria Couch, Fergus J. Olson, Janet E. Slettedahl, Seth Vachon, Celine Giles, Graham G. Milne, Roger L. McLean, Catriona Haiman, Christopher A. Henderson, Brian E. Schumacher, Fredrick Le Marchand, Loic Simard, Jacques Goldberg, Mark S. Labrèche, France Dumont, Martine Kristensen, Vessela Alnæs, Grethe Grenaker Nord, Silje Borresen-Dale, Anne-Lise Zheng, Wei Deming-Halverson, Sandra Shrubsole, Martha Long, Jirong Winqvist, Robert Pylkäs, Katri Jukkola-Vuorinen, Arja Grip, Mervi Andrulis, Irene L. Knight, Julia A. Glendon, Gord Tchatchou, Sandrine Devilee, Peter Tollenaar, Robertus A. E. M. Seynaeve, Caroline M. Van Asperen, Christi J. Garcia-Closas, Montserrat Figueroa, Jonine Chanock, Stephen J. Lissowska, Jolanta Czene, Kamila Darabi, Hatef Eriksson, Mikael Klevebring, Daniel Hooning, Maartje J. Hollestelle, Antoinette van Deurzen, Carolien H. M. Kriege, Mieke Hall, Per Li, Jingmei Liu, Jianjun Humphreys, Keith Cox, Angela Cross, Simon S. Reed, Malcolm W. R. Pharoah, Paul D. P. Dunning, Alison M. Shah, Mitul Perkins, Barbara J. Jakubowska, Anna Lubinski, Jan Jaworska-Bieniek, Katarzyna Durda, Katarzyna Ashworth, Alan Swerdlow, Anthony Jones, Michael Schoemaker, Minouk J. Meindl, Alfons Schmutzler, Rita K. Olswold, Curtis Slager, Susan Toland, Amanda E. Yannoukakos, Drakoulis Muir, Kenneth Lophatananon, Artitaya Stewart-Brown, Sarah Siriwanarangsan, Pornthep Matsuo, Keitaro Ito, Hidema Iwata, Hiroji Ishiguro, Junko Wu, Anna H. Tseng, Chiu-chen Van Den Berg, David Stram, Daniel O. Teo, Soo Hwang Yip, Cheng Har Kang, Peter Ikram, Mohammad Kamran Shu, Xiao-Ou Lu, Wei Gao, Yu-Tang Cai, Hui Kang, Daehee Choi, Ji-Yeob Park, Sue K. Noh, Dong-Young Hartman, Mikael Miao, Hui Lim, Wei Yen Lee, Soo Chin Sangrajrang, Suleeporn Gaborieau, Valerie Brennan, Paul Mckay, James Wu, Pei-Ei Hou, Ming-Feng Yu, Jyh-Cherng Shen, Chen-Yang Blot, William Cai, Qiuyin Signorello, Lisa B. Luccarini, Craig Bayes, Caroline Ahmed, Shahana Maranian, Mel Healey, Catherine S. González-Neira, Anna Pita, Guillermo Alonso, M. Rosario Álvarez, Nuria Herrero, Daniel Tessier, Daniel C. Vincent, Daniel Bacot, Francois Hunter, David J. Lindstrom, Sara Dennis, Joe Michailidou, Kyriaki Bolla, Manjeet K. Easton, Douglas F. dos Santos Silva, Isabel Fletcher, Olivia Peto, Julian Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2 |
title | Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2 |
title_full | Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2 |
title_fullStr | Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2 |
title_full_unstemmed | Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2 |
title_short | Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2 |
title_sort | fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2 |
topic | Association Studies Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406292/ https://www.ncbi.nlm.nih.gov/pubmed/25652398 http://dx.doi.org/10.1093/hmg/ddv035 |
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