Cargando…

Meroterpenoid Chrodrimanins Are Selective and Potent Blockers of Insect GABA-Gated Chloride Channels

Meroterpenoid chrodrimanins, produced from Talaromyces sp. YO-2, are known to paralyze silkworm (Bombyx mori) larvae, but their target is unknown. We have investigated the actions of chrodrimanin B on ligand-gated ion channels of silkworm larval neurons using patch-clamp electrophysiology. Chrodrima...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Yan, Furutani, Shogo, Ihara, Makoto, Ling, Yun, Yang, Xinling, Kai, Kenji, Hayashi, Hideo, Matsuda, Kazuhiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406737/ https://www.ncbi.nlm.nih.gov/pubmed/25902139 http://dx.doi.org/10.1371/journal.pone.0122629

Ejemplares similares

A Fungal Metabolite Asperparaline A Strongly and Selectively Blocks Insect Nicotinic Acetylcholine Receptors: The First Report on the Mode of Action
por: Hirata, Koichi, et al.
Publicado: (2011)

GluCl a target of indole alkaloid okaramines: a 25 year enigma solved
por: Furutani, Shogo, et al.
Publicado: (2014)

The fungal alkaloid Okaramine-B activates an L-glutamate-gated chloride channel from Ixodes scapularis, a tick vector of Lyme disease
por: Furutani, Shogo, et al.
Publicado: (2018)

Agonist and antagonist properties of an insect GABA-gated chloride channel (RDL) are influenced by heterologous expression conditions
por: Smelt, Charles L. C., et al.
Publicado: (2021)

Progress in the Chemistry of Macrocyclic Meroterpenoids
por: Shurpik, Dmitriy N., et al.
Publicado: (2020)

Muscarinic acetylcholine receptor activation synergizes the knockdown and toxicity of GABA‐gated chloride channel insecticides
por: Xie, Na, et al.
Publicado: (2022)

β subunits of GABA(A) receptors form proton-gated chloride channels: Insights into the molecular basis
por: Garifulina, Aleksandra, et al.
Publicado: (2022)

A photoswitchable GABA receptor channel blocker
por: Maleeva, Galyna, et al.
Publicado: (2019)

Simultaneous Optical Recording in Multiple Cells by Digital Holographic Microscopy of Chloride Current Associated to Activation of the Ligand-Gated Chloride Channel GABA(A) Receptor
por: Jourdain, Pascal, et al.
Publicado: (2012)

A modular synthesis of tetracyclic meroterpenoid antibiotics
por: Wildermuth, Raphael, et al.
Publicado: (2017)

Divergent Strategy in Marine Tetracyclic Meroterpenoids Synthesis
por: Rosales Martínez, Antonio, et al.
Publicado: (2021)

Meroterpenoid Synthesis via Sequential Polyketide Aromatization and Cationic Polyene Cyclization: Total Syntheses of (+)-Hongoquercin A and B and Related Meroterpenoids
por: Ma, Tsz-Kan, et al.
Publicado: (2018)

Meroterpenoids from Neosetophoma sp.: A Dioxa[4.3.3]propellane Ring System, Potent Cytotoxicity, and Prolific Expression
por: El-Elimat, Tamam, et al.
Publicado: (2019)

Biological activities of meroterpenoids isolated from different sources
por: Fuloria, Neeraj Kumar, et al.
Publicado: (2022)

Discovery of branching meroterpenoid biosynthetic pathways in Aspergillus insuetus: involvement of two terpene cyclases with distinct cyclization modes
por: Tang, Jia, et al.
Publicado: (2022)

The mechanism of loop C-neonicotinoid interactions at insect nicotinic acetylcholine receptor α1 subunit predicts resistance emergence in pests
por: Shimada, Shota, et al.
Publicado: (2020)

New Formyl Phloroglucinol Meroterpenoids from the Leaves of Eucalyptus robusta
por: Shang, Zhi-Chun, et al.
Publicado: (2016)

Terretonin N: A New Meroterpenoid from Nocardiopsis sp.
por: Hamed, Abdelaaty, et al.
Publicado: (2018)

Cytotoxic and N-Acetyltransferase Inhibitory Meroterpenoids from Ganoderma cochlear
por: Cheng, Li-Zhi, et al.
Publicado: (2018)

Structurally Diverse Polymethylated Phloroglucinol Meroterpenoids from Baeckea frutescens
por: Zhi, Yin-E, et al.
Publicado: (2018)

Reconstitution of Polyketide-Derived Meroterpenoid Biosynthetic Pathway in Aspergillus oryzae
por: Awakawa, Takayoshi, et al.
Publicado: (2021)

Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology †
por: Nazir, Mamona, et al.
Publicado: (2021)

Antiparasitic Meroterpenoids Isolated from Memnoniella dichroa CF-080171
por: Annang, Frederick Boye, et al.
Publicado: (2023)

Meroterpenoids with Immunosuppressive Activity from Edible Fungus Craterellus odoratus
por: Dai, Quan, et al.
Publicado: (2023)

Molecular Characterization of Agonists That Bind to an Insect GABA Receptor†
por: McGonigle, Ian, et al.
Publicado: (2010)

Gating the glutamate gate of CLC-2 chloride channel by pore occupancy
por: De Jesús-Pérez, José J., et al.
Publicado: (2016)

Guajadials C-F, four unusual meroterpenoids from Psidium guajava
por: Gao, Yuan, et al.
Publicado: (2013)

Stachybotrychromenes A–C: novel cytotoxic meroterpenoids from Stachybotrys sp.
por: Jagels, Annika, et al.
Publicado: (2018)

Total Synthesis of Bioactive Marine Meroterpenoids: The Cases of Liphagal and Frondosin B
por: Zong, Yan, et al.
Publicado: (2018)

Meroterpenoids from Ganoderma Species: A Review of Last Five Years
por: Peng, Xingrong, et al.
Publicado: (2018)

Meroterpenoids and Isocoumarinoids from a Myrothecium Fungus Associated with Apocynum venetum
por: Xu, Yanchao, et al.
Publicado: (2018)

Correction to: Structurally Diverse Polymethylated Phloroglucinol Meroterpenoids from Baeckea frutescens
por: Zhi, Yin-E, et al.
Publicado: (2018)

Bakuchiol – a natural meroterpenoid: structure, isolation, synthesis and functionalization approaches
por: Adarsh Krishna, T. P., et al.
Publicado: (2022)

Terminal Cyclohexane-Type Meroterpenoids from the Fruiting Bodies of Ganoderma cochlear
por: Qin, Fu-Ying, et al.
Publicado: (2021)

Molecular Determinants of Agonist Selectivity in Glutamate-Gated Chloride Channels Which Likely Explain the Agonist Selectivity of the Vertebrate Glycine and GABA(A)-ρ Receptors
por: Blarre, Thomas, et al.
Publicado: (2014)

The pharmacological profile of ELIC, a prokaryotic GABA-gated receptor
por: Thompson, Andrew J., et al.
Publicado: (2012)

Intracellular chloride concentration influences the GABA(A) receptor subunit composition
por: Succol, Francesca, et al.
Publicado: (2012)

Salmon lice (Lepeophtheirus salmonis) showing varying emamectin benzoate susceptibilities differ in neuronal acetylcholine receptor and GABA-gated chloride channel mRNA expression
por: Carmichael, Stephen N, et al.
Publicado: (2013)

Correction: Molecular Determinants of Agonist Selectivity in Glutamate-Gated Chloride Channels Which Likely Explain the Agonist Selectivity of the Vertebrate Glycine and GABA(A)-ρ Receptors
Publicado: (2014)

Facilitation of hERG Activation by Its Blocker: A Mechanism to Reduce Drug-Induced Proarrhythmic Risk
por: Furutani, Kazuharu
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_s6slnu6rvtk939baolo7t0vua4