The transcription factor IRF1 and guanylate-binding proteins target AIM2 inflammasome activation by Francisella infection

Inflammasomes are critical for mounting host defense against pathogens. The molecular mechanisms controlling activation of the AIM2 inflammasome in response to different cytosolic pathogens is unclear. Here, we show that the transcription factor IRF1 is the upstream molecule leading to AIM2 inflamma...

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Detalles Bibliográficos
Autores principales: Man, Si Ming, Karki, Rajendra, Malireddi, R.K. Subbarao, Neale, Geoffrey, Vogel, Peter, Yamamoto, Masahiro, Lamkanfi, Mohamed, Kanneganti, Thirumala-Devi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406811/
https://www.ncbi.nlm.nih.gov/pubmed/25774715
http://dx.doi.org/10.1038/ni.3118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406811/
https://www.ncbi.nlm.nih.gov/pubmed/25774715
http://dx.doi.org/10.1038/ni.3118

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