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The helicase senataxin suppresses the antiviral transcriptional response and controls viral biogenesis

The human helicase senataxin (SETX) is implicated in the neurodegenerative diseases amyotrophic lateral sclerosis (ALS4) and ataxia with oculomotor apraxia (AOA2). Here, we reveal a role for SETX in controlling the antiviral response. Cells depleted for SETX and AOA2 patient-derived SETX-deficient c...

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Detalles Bibliográficos
Autores principales:	Miller, Matthew S., Rialdi, Alexander, Ho, Jessica Sook Yuin, Tilove, Micah, Martinez-Gil, Luis, Moshkina, Natasha P., Peralta, Zuleyma, Noel, Justine, Melegari, Camilla, Maestre, Ana, Mitsopoulos, Panagiotis, Madrenas, Joaquín, Heinz, Sven, Benner, Chris, Young, John A. T., Feagins, Alicia R., Basler, Christopher, Fernandez-Sesma, Ana, Becherel, Olivier J., Lavin, Martin F., van Bakel, Harm, Marazzi, Ivan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406851/ https://www.ncbi.nlm.nih.gov/pubmed/25822250 http://dx.doi.org/10.1038/ni.3132

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