Cargando…
Dendritic Cell-Based Cancer Immunotherapy against Multiple Myeloma: From Bench to Clinic
Although the introduction of stem cell transplantation and novel agents has improved survival, multiple myeloma (MM) is still difficult to cure. Alternative approaches are clearly needed to prolong the survival of patients with MM. Dendritic cell (DC) therapy is a very promising tool immunologically...
| Autores principales: | , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Chonnam National University Medical School
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406989/ https://www.ncbi.nlm.nih.gov/pubmed/25914874 http://dx.doi.org/10.4068/cmj.2015.51.1.1 |
| _version_ | 1782367839619907584 |
|---|---|
| author | Hoang, My-Dung Jung, Sung-Hoon Lee, Hyun-Ju Lee, Youn-Kyung Nguyen-Pham, Thanh-Nhan Choi, Nu-Ri Vo, Manh-Cuong Lee, Seung-Shin Ahn, Jae-Sook Yang, Deok-Hwan Kim, Yeo-Kyeoung Kim, Hyeoung-Joon Lee, Je-Jung |
| author_facet | Hoang, My-Dung Jung, Sung-Hoon Lee, Hyun-Ju Lee, Youn-Kyung Nguyen-Pham, Thanh-Nhan Choi, Nu-Ri Vo, Manh-Cuong Lee, Seung-Shin Ahn, Jae-Sook Yang, Deok-Hwan Kim, Yeo-Kyeoung Kim, Hyeoung-Joon Lee, Je-Jung |
| author_sort | Hoang, My-Dung |
| collection | PubMed |
| description | Although the introduction of stem cell transplantation and novel agents has improved survival, multiple myeloma (MM) is still difficult to cure. Alternative approaches are clearly needed to prolong the survival of patients with MM. Dendritic cell (DC) therapy is a very promising tool immunologically in MM. We developed a method to generate potent DCs with increased Th1 polarization and migration ability for inducing strong myeloma-specific cytotoxic T lymphocytes. In this review, we discuss how the efficacy of cancer immunotherapy using DCs can be improved in MM. |
| format | Online Article Text |
| id | pubmed-4406989 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | Chonnam National University Medical School |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-44069892015-04-24 Dendritic Cell-Based Cancer Immunotherapy against Multiple Myeloma: From Bench to Clinic Hoang, My-Dung Jung, Sung-Hoon Lee, Hyun-Ju Lee, Youn-Kyung Nguyen-Pham, Thanh-Nhan Choi, Nu-Ri Vo, Manh-Cuong Lee, Seung-Shin Ahn, Jae-Sook Yang, Deok-Hwan Kim, Yeo-Kyeoung Kim, Hyeoung-Joon Lee, Je-Jung Chonnam Med J Review Article Although the introduction of stem cell transplantation and novel agents has improved survival, multiple myeloma (MM) is still difficult to cure. Alternative approaches are clearly needed to prolong the survival of patients with MM. Dendritic cell (DC) therapy is a very promising tool immunologically in MM. We developed a method to generate potent DCs with increased Th1 polarization and migration ability for inducing strong myeloma-specific cytotoxic T lymphocytes. In this review, we discuss how the efficacy of cancer immunotherapy using DCs can be improved in MM. Chonnam National University Medical School 2015-04 2015-04-14 /pmc/articles/PMC4406989/ /pubmed/25914874 http://dx.doi.org/10.4068/cmj.2015.51.1.1 Text en © Chonnam Medical Journal, 2015 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Review Article Hoang, My-Dung Jung, Sung-Hoon Lee, Hyun-Ju Lee, Youn-Kyung Nguyen-Pham, Thanh-Nhan Choi, Nu-Ri Vo, Manh-Cuong Lee, Seung-Shin Ahn, Jae-Sook Yang, Deok-Hwan Kim, Yeo-Kyeoung Kim, Hyeoung-Joon Lee, Je-Jung Dendritic Cell-Based Cancer Immunotherapy against Multiple Myeloma: From Bench to Clinic |
| title | Dendritic Cell-Based Cancer Immunotherapy against Multiple Myeloma: From Bench to Clinic |
| title_full | Dendritic Cell-Based Cancer Immunotherapy against Multiple Myeloma: From Bench to Clinic |
| title_fullStr | Dendritic Cell-Based Cancer Immunotherapy against Multiple Myeloma: From Bench to Clinic |
| title_full_unstemmed | Dendritic Cell-Based Cancer Immunotherapy against Multiple Myeloma: From Bench to Clinic |
| title_short | Dendritic Cell-Based Cancer Immunotherapy against Multiple Myeloma: From Bench to Clinic |
| title_sort | dendritic cell-based cancer immunotherapy against multiple myeloma: from bench to clinic |
| topic | Review Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406989/ https://www.ncbi.nlm.nih.gov/pubmed/25914874 http://dx.doi.org/10.4068/cmj.2015.51.1.1 |
| work_keys_str_mv | AT hoangmydung dendriticcellbasedcancerimmunotherapyagainstmultiplemyelomafrombenchtoclinic AT jungsunghoon dendriticcellbasedcancerimmunotherapyagainstmultiplemyelomafrombenchtoclinic AT leehyunju dendriticcellbasedcancerimmunotherapyagainstmultiplemyelomafrombenchtoclinic AT leeyounkyung dendriticcellbasedcancerimmunotherapyagainstmultiplemyelomafrombenchtoclinic AT nguyenphamthanhnhan dendriticcellbasedcancerimmunotherapyagainstmultiplemyelomafrombenchtoclinic AT choinuri dendriticcellbasedcancerimmunotherapyagainstmultiplemyelomafrombenchtoclinic AT vomanhcuong dendriticcellbasedcancerimmunotherapyagainstmultiplemyelomafrombenchtoclinic AT leeseungshin dendriticcellbasedcancerimmunotherapyagainstmultiplemyelomafrombenchtoclinic AT ahnjaesook dendriticcellbasedcancerimmunotherapyagainstmultiplemyelomafrombenchtoclinic AT yangdeokhwan dendriticcellbasedcancerimmunotherapyagainstmultiplemyelomafrombenchtoclinic AT kimyeokyeoung dendriticcellbasedcancerimmunotherapyagainstmultiplemyelomafrombenchtoclinic AT kimhyeoungjoon dendriticcellbasedcancerimmunotherapyagainstmultiplemyelomafrombenchtoclinic AT leejejung dendriticcellbasedcancerimmunotherapyagainstmultiplemyelomafrombenchtoclinic |