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Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3(+) and Foxp3(−) T cells

Costimulatory signals by CD28 are critical for thymic regulatory T-cell (Treg) development. To determine the functional relevance of CD28 for peripheral Treg post thymic selection, we crossed the widely used Forkhead box protein 3 (Foxp3)-CreYFP mice to mice bearing a conditional Cd28 allele. Treg-s...

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Detalles Bibliográficos
Autores principales:	Franckaert, Dean, Dooley, James, Roos, Evelyne, Floess, Stefan, Huehn, Jochen, Luche, Herve, Fehling, Hans Joerg, Liston, Adrian, Linterman, Michelle A, Schlenner, Susan M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407013/ https://www.ncbi.nlm.nih.gov/pubmed/25533288 http://dx.doi.org/10.1038/icb.2014.108

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