Bio301: A Web-Based EST Annotation Pipeline That Facilitates Functional Comparison Studies

In this postgenomic era, a huge volume of information derived from expressed sequence tags (ESTs) has been constructed for functional description of gene expression profiles. Comparative studies have become more and more important to researchers of biology. In order to facilitate these comparative s...

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Detalles Bibliográficos
Autores principales: Chen, Yen-Chen, Chen, Yun-Ching, Lin, Wen-Dar, Hsiao, Chung-Der, Chiu, Hung-Wen, Ho, Jan-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407203/
https://www.ncbi.nlm.nih.gov/pubmed/25969743
http://dx.doi.org/10.5402/2012/139842
Descripción
Sumario:In this postgenomic era, a huge volume of information derived from expressed sequence tags (ESTs) has been constructed for functional description of gene expression profiles. Comparative studies have become more and more important to researchers of biology. In order to facilitate these comparative studies, we have constructed a user-friendly EST annotation pipeline with comparison tools on an integrated EST service website, Bio301. Bio301 includes regular EST preprocessing, BLAST similarity search, gene ontology (GO) annotation, statistics reporting, a graphical GO browsing interface, and microarray probe selection tools. In addition, Bio301 is equipped with statistical library comparison functions using multiple EST libraries based on GO annotations for mining meaningful biological information.

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