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Structural and Mechanistic Analysis of the Slx1-Slx4 Endonuclease

The SLX1-SLX4 endonuclease required for homologous recombination and DNA repair in eukaryotic cells cleaves a variety of branched DNA structures. The nuclease subunit SLX1 is activated by association with a scaffolding protein SLX4. At the present time, little is known about the structure of SLX1-SL...

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Detalles Bibliográficos
Autores principales:	Gaur, Vineet, Wyatt, Haley D.M., Komorowska, Weronika, Szczepanowski, Roman H., de Sanctis, Daniele, Gorecka, Karolina M., West, Stephen C., Nowotny, Marcin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2015
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407285/ https://www.ncbi.nlm.nih.gov/pubmed/25753413 http://dx.doi.org/10.1016/j.celrep.2015.02.019

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